Background: Carbonate hydroxyapatite (CHA) is used as a scaffold to repair bone resorption. Alveolar bone resorption in periodontitis caused by an infection requires the presence of an antibacterial to support bone regeneration. Human ?-defensin 3 (HBD3) is an antimicrobial peptide. The local application of the HBD3 antimicrobial is beneficial to inhibiting drug resistance and protecting tissue regeneration against invasive bacteria. Purpose: This study aims to investigate the effect of the administration of a combination of CHA with HBD3 on the collagen density of periodontitis rats (Sprague Dawley). Methods: This study was a true experimental study with a post-test control group design. Thirty-two Sprague Dawley animal models were randomly blind selected placed under anaesthetic, then a 2-mm silk ligature was attached as a ligation to the mandibular incisors for 14 days in order to generate periodontitis. The study subjects were divided into two groups, the group with CHA and CHA loaded HBD3 (CHA + HBD3) implantation. On days 7, 14, 21 and 28, four rats were taken randomly from each group for decapitation, followed by histological processing and examination with trichome Mallory staining. The data was analysed using the Kruskal Wallis test (p<0.05). Results: An increase in collagen density during the healing process was found. There was a significant difference between CHA and CHA+HBD (p=0.004 and p=0.008; p<0.05) in collagen density between the groups. Conclusion: The combination of CHA and HBD3 can enhance the collagen density in periodontitis Sprague Dawley rats, compared to CHA only groups.
| Published by | Universitas Airlangga |
| Journal Name | Dental Journal (Majalah Kedokteran Gigi) |
| Contact Phone | - |
| Contact Name | Saka Winias |
| Contact Email | saka.winias@gmail.com |
| Location | Kota surabaya, Jawa timur INDONESIA |
| Website | MKG| https://e-journal.unair.ac.id/index.php/MKG| |
| ISSN | ISSN : 19783728, EISSN : 24429740, DOI : -, |
| Core Subject | Health, |
| Meta Subject | Dentistry, |
| Meta Desc | The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. |
| Penulis | Andriani, Ika , Meiyanto, Edy , Suryono, S. , Ana, Ika Dewi |
| Publisher Article | Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en |
| Subtitle Article | Dental Journal (Majalah Kedokteran Gigi) Vol 53, No 2 (2020): (June 2020) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://e-journal.unair.ac.id/… |
| DOI | https://doi.org/10.20473/j.djmkg.v5… |
| DOI Number | DOI: 10.20473/j.djmkg.v53.i2.p76-80 |
| Download Article [1] | https://e-journal.unair.ac.id/MKG/articl… |
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