HDAC5

L'istone deacetilasi 5, noto anche come HDAC5, è un enzima che nell'uomo è codificato dal gene HDAC5.[1][2][3]

Funzione

Gli istoni svolgono un ruolo critico nella regolazione trascrizionale, progressione del ciclo cellulare. L'acetilazione degli istoni e la deacetilazione altera la struttura cromosomica e colpisce i fattori di accesso alla trascrizione del DNA. La proteina codificata da questo gene appartiene alla famiglia di classeII dell'istone ACUC / apha deacetilasi. Ha l'attività deacetilasi dell'istone e reprime la trascrizione quando legato ad un promotore. Sembra interagire con un complesso multiproteico della famiglia dell'HDAC3. Interagisce anche con le proteine miocitiche dell'MEF2, con conseguente repressione dei geni MEF2-dipendenti. Questo gene si pensa sia associato con il tumore al colon: sono state individuate due isoforme.[3]

La regolazione dell'AMP-activated protein kinase del GLUT4 trasportatore del glucosio avviene attraverso la fosforilazione dell' HDAC5.[4]

L'HDAC5 è coinvolto nei processi di consolidamento della memoria e suggerisce che lo sviluppo di più selettivi inibitori dell'istone deacetilasi (HDAC) potrebbero essere utili nel trattamento della malattia di Alzheimer[5]

Note

  1. ^ Grozinger CM, Hassig CA, Schreiber SL, Three proteins define a class of human histone deacetylases related to yeast Hda1p, in Proc Natl Acad Sci U S A, vol. 96, n. 9, giugno 1999, pp. 4868–73, DOI:10.1073/pnas.96.9.4868, PMC 21783, PMID 10220385.
  2. ^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ, <652::AID-IJC7>3.0.CO;2-P Characterization of human colon cancer antigens recognized by autologous antibodies, in Int J Cancer, vol. 76, n. 5, giugno 1998, pp. 652–8, DOI:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P, PMID 9610721.
  3. ^ a b Entrez Gene: HDAC5 histone deacetylase 5, su ncbi.nlm.nih.gov.
  4. ^ McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M, AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5, in Diabetes, vol. 57, n. 4, 2008, pp. 860–867, DOI:10.2337/db07-0843, PMID 18184930.
  5. ^ Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A, Loss of HDAC5 impairs memory function: implications for Alzheimer's disease, in J Alzheimers Dis, vol. 33, n. 1, gennaio 2013, pp. 35–44, DOI:10.3233/JAD-2012-121009, PMID 22914591.

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