Laninamivir

Laninamivir

Structure du laninamivir
Identification
Synonymes

CS-8958

No CAS 203120-17-6
PubChem 502272
SMILES
InChI
Propriétés chimiques
Formule C13H22N4O7
Masse molaire[1] 346,336 4 ± 0,014 8 g/mol
C 45,08 %, H 6,4 %, N 16,18 %, O 32,34 %,
Considérations thérapeutiques
Classe thérapeutique Antiviral antigrippal
Voie d’administration Inhalation

Unités du SI et CNTP, sauf indication contraire.

Le laninamivir (CS-8958) est un antiviral inhibiteur de la neuraminidase étudié en vue d'une possible application comme traitement, voire comme prophylaxie, contre le virus de la grippe A et le virus de la grippe B[2] actuellement en phase III d'essai clinique[3]. Il a été approuvé en 2010 au Japon pour le traitement de la grippe.

Notes et références

  1. Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.
  2. (en) Makoto Yamashita, Takanori Tomozawa, Masayo Kakuta, Akane Tokumitsu, Hatsumi Nasu et Shuku Kubo, « CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity », Antimicrobial Agents and Chemotherapy, vol. 53, no 1,‎ , p. 186-192 (PMID 18955520, PMCID 2612152, DOI 10.1128/AAC.00333-08, lire en ligne)
  3. (en) Frederick Hayden, « Developing New Antiviral Agents for Influenza Treatment: What Does the Future Hold? », Clinical Infectious Diseases, vol. 48, no Supplement 1,‎ , S3-13 (PMID 19067613, DOI 10.1086/591851, lire en ligne)

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