Rezvilutamide

Rezvilutamide
Clinical data
Other namesSHR3680
Drug classNonsteroidal antiandrogen
Identifiers
  • 4-[3-[4-[(2S)-2,3-dihydroxypropoxy]phenyl]-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H20F3N3O4S
Molar mass479.47 g·mol−1
3D model (JSmol)
  • CC1(C(=O)N(C(=S)N1C2=CC=C(C=C2)OC[C@H](CO)O)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
  • InChI=1S/C22H20F3N3O4S/c1-21(2)19(31)27(15-4-3-13(10-26)18(9-15)22(23,24)25)20(33)28(21)14-5-7-17(8-6-14)32-12-16(30)11-29/h3-9,16,29-30H,11-12H2,1-2H3/t16-/m0/s1
  • Key:KRBMOYIWQCZVHA-INIZCTEOSA-N

Rezvilutamide (INNTooltip International Nonproprietary Name),[1][2] sold under the brand name Ariane, is a nonsteroidal antiandrogen which is approved for the treatment of prostate cancer in China and is or was under development for the treatment of breast cancer.[3][4][5] It is a selective androgen receptor antagonist with reduced brain distribution compared to the structurally related nonsteroidal antiandrogen enzalutamide.[3][5] The drug was developed by Jiangsu Hengrui Medicine.[3] Other structural analogues of rezvilutamide that are also used as antiandrogens besides enzalutamide include apalutamide and proxalutamide.

References

  1. ^ "Rezvilutamide". chemidplus. U.S. National Library of Medicine.
  2. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). WHO.
  3. ^ a b c "SHR 3680". AdisInsight.
  4. ^ Keam SJ (January 2023). "Rezvilutamide: First Approval". Drugs. 83 (2): 189–193. doi:10.1007/s40265-022-01831-y. PMID 36630077. S2CID 255593586.
  5. ^ a b Qin X, Han W, Luo H, Du C, Zou Q, Sun Z, et al. (2020). "SHR3680, a novel antiandrogen, for the treatment of metastatic castration-resistant prostate cancer (mCRPC): A phase I/II study". Journal of Clinical Oncology. 38 (6_suppl): 90. doi:10.1200/JCO.2020.38.6_suppl.90. S2CID 214027454.


Read other articles:

Disambiguazione – Se stai cercando altri significati, vedi Novembre (disambigua). Questa voce sull'argomento cronologia è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Pieter Bruegel il Vecchio, Ritorno delle greggi, V ambientato in novembre Novembre è l'undicesimo mese dell'anno secondo il calendario gregoriano e il terzo e ultimo mese dell'autunno nell'emisfero boreale e della primavera nell'emisfero …

此条目序言章节没有充分总结全文内容要点。 (2019年3月21日)请考虑扩充序言,清晰概述条目所有重點。请在条目的讨论页讨论此问题。 哈萨克斯坦總統哈薩克總統旗現任Қасым-Жомарт Кемелұлы Тоқаев卡瑟姆若马尔特·托卡耶夫自2019年3月20日在任任期7年首任努尔苏丹·纳扎尔巴耶夫设立1990年4月24日(哈薩克蘇維埃社會主義共和國總統) 哈萨克斯坦 哈萨克斯坦政府與…

Aras-wangi Calocedrus Calocedrus decurrensCalifornia incense cedarTaksonomiDivisiPinophytaKelasPinopsidaOrdoPinalesFamiliCupressaceaeSubfamiliCupressoideaeGenusCalocedrus Tata namaGender of a scientific name of a genusfeminin lbs Calocedrus, aras-wangi atau aras-dupa adalah genus pohon jenis konifera dalam keluarga cemara Cupressaceae yang pertama kali dideskripsikan sebagai genus pada tahun 1873.[1] Tiga spesies berasal dari Asia bagian timur dan satu spesies berasal dari Amerika Utara …

Calcium channel blocker medication DiltiazemClinical dataPronunciation/dɪlˈtaɪəzɛm/ Trade namesCardizem, Dilacor XR, Cartia XT, othersAHFS/Drugs.comMonographMedlinePlusa684027License data US DailyMed: Diltiazem Pregnancycategory AU: C[1] Routes ofadministrationBy mouth, intravenousDrug classNondihydropyridine calcium channel blockerATC codeC05AE03 (WHO) C08DB01 (WHO)Legal statusLegal status AU: S4 (Prescription only) UK: POM (Prescription…

American reality television series This article is about the American edition. For other editions, see Celebrity Big Brother. For the regular edition of the series, see Big Brother (American TV series). Celebrity Big BrotherAlso known as Big Brother: Celebrity Edition Celebrity Big Brother U.S. GenreReality competitionCreated byJohn de MolBased onBig Brotherby John de MolPresented byJulie Chen MoonvesStarringCelebrity Big Brother houseguestsVoices ofDon WollmanNarrated byClayton HalseyTheme musi…

Public museum in Hong Kong This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Hong Kong Museum of Coastal Defence – news · newspapers · books · scholar · JSTOR (July 2015) (Learn how and when to remove this message) 22°16′55″N 114°14′8″E / 22.28194°N 114.23556°E / 22.28194; 114.…

Pour les articles homonymes, voir Karakul. Cet article est une ébauche concernant un mammifère. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations du projet zoologie. Karakul Région d’origine Région Asie centrale Caractéristiques Poids 60-70 kg (bélier)40-50 kg (brebis) Statut FAO (conservation) Non menacé Autre Diffusion internationale Utilisation lait, viande et laine modifier  Le karakul ou caracul est une race de moutons à poil…

Designation given to a Hindu temple priest who performs puja A pujari performing the puja rituals in Varanasi, India. Pūjari is a designation given to a Hindu temple priest who performs pūja. The word comes from the Sanskrit word पूजा meaning worship. They are responsible for performing temple rituals, including pūjā and aarti. Pujari are mainly drawn from the Hindu Brahmin and Billava[1][2][3] History This section is empty. You can help by adding to it. (Nove…

Kyle Naughton Kyle Naughton bermain untuk Leicester CityInformasi pribadiNama lengkap Kyle NaughtonTanggal lahir 17 November 1988 (umur 35)Tempat lahir Sheffield, EnglandTinggi 1,80 m (5 ft 11 in)Posisi bermain Bek KananInformasi klubKlub saat ini Swansea CityNomor 26Karier junior1996–2008 Sheffield UnitedKarier senior*Tahun Tim Tampil (Gol)2008–2009 Sheffield United 40 (1)2008 → Gretna (pinjaman) 18 (0)2009–2015 Tottenham Hotspur 42 (0)2010 → Middlesbrough (pinjama…

JatinomKecamatanPeta lokasi Kecamatan JatinomNegara IndonesiaProvinsiJawa TengahKabupatenKlatenPemerintahan • Camat-Populasi • Total49,611 jiwaKode Kemendagri33.10.20 Kode BPS3310220 Luas35,53 km²Desa/kelurahan18 Makam Ki Ageng Gribig di Jatinom Green Canyon di Jatinom Jatinom (bahasa Jawa: ꦗꦠꦶꦤꦺꦴꦩ꧀, translit. Jatinom) adalah nama suatu kecamatan di Kabupaten Klaten sekaligus kota pusat pemerintahannya. Jatinom terletak pada jalur utama yang…

Untuk Antananarivo sebagai provinsi, lihat: Provinsi Antananarivo. Antananarivo TananariveIbu kotaAntananarivo saat matahari tenggelam, Maret 2005Julukan: TanaLokasi Antananarivo di MadagaskarNegara MadagaskarDidirikan1625Pemerintahan • Wali kotadipertentangkanLuas • Luas perairan88 km2 (34 sq mi)Ketinggian1.276 m (4,186 ft)Populasi (2001 estimasi) • Ibu kota903,450 • Kepadatan10,266,5/km2 (26,590/sq mi)…

CCTV-2 财经CCTV-2 KeuanganDiluncurkan1 Mei 1973PemilikChina Central TelevisionNegara Republik Rakyat TiongkokSitus webCCTV-2Televisi InternetCNTV Ai BuguCCTV-2 CCTV-2 adalah saluran keuangan (sebelumnya saluran ekonomi hingga 24 Agustus 2009) yang terfokus pada jaringan CCTV (China Central Television) di Republik Rakyat Tiongkok. Fokus utama dari saluran ini adalah: Konservasi energi Bursa saham Permainan Beberapa acara 8:00 AM: 第一时间, First Focus 11:50 AM: 全球资讯榜, Global Infor…

T

Tمعلومات عامةصنف فرعي من مِحْرَف جزء من إخطاطة لاتينيةPolish alphabet (en) أبجدية إنجليزية الرمز -TangoT تعديل - تعديل مصدري - تعديل ويكي بيانات T \ تيه \ الحرف العشرون من الأبجدية اللاتينية. وهو الحرف الساكن الأكثر شيوعًا وثاني الأحرف الأكثر شيوعًا في نصوص اللغة الإنجليزية.[1] مراجع ^ Le…

العلاقات المالديفية الباربادوسية جزر المالديف باربادوس   المالديف   باربادوس تعديل مصدري - تعديل   العلاقات المالديفية الباربادوسية هي العلاقات الثنائية التي تجمع بين المالديف وباربادوس.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ومرجعي…

River in New York, United States Map of the Croton River watershed The Croton River (/ˈkroʊtən/ KROH-tən) is a river in southern New York with three principal tributaries: the West Branch, Middle Branch, and East Branch. Their waters, all part of the New York City water supply system,[1] join downstream from the Croton Falls Reservoir.[a] Together, their waters and the reservoirs linked to them represent the northern half of the New York City water system's Croton Watershed. …

  此條目介紹的是自然地理學上的海岸線。关于海岸線的其它含義,请见「海岸線 (消歧義)」。 孟加拉吉大港海岸線 海岸線,海水面和陸地的分界線。 定义 在自然地理学上,海岸线通常是用海岸邊沙丘的最高點連線定義海岸线,在海岸悬崖地区则以悬崖线来划分。海岸线与大潮最低水位之间的地区称为滨岸。 对于测绘学而言,在海图上,有潮海为多年平均大潮高潮的…

بيز بلافنا دادينت   الموقع كانتون غراوبوندن، سويسرا المنطقة غراوبوندن  إحداثيات 46°42′31″N 10°13′26″E / 46.708611111111°N 10.223777777778°E / 46.708611111111; 10.223777777778   الارتفاع 3,167 متر (10,390 قدم) السلسلة جبال الألب سيسفيينا النتوء 490 متر (1,610 قدم) الوصول الأول 1891 قائمة جبال الأل…

Giovanni TruppiGiovanni Truppi in concerto a Milano nel 2019 Nazionalità Italia GenereMusica d'autoreIndie rock Periodo di attività musicale2010 – in attività EtichettaCinico Disincanto, Jaba Jaba Music, Woodworm, Virgin Album pubblicati7 Studio5 Raccolte2 Sito ufficiale Modifica dati su Wikidata · Manuale Giovanni Truppi (Napoli, 21 febbraio 1981) è un cantautore e musicista italiano. Indice 1 Biografia 2 Opere 2.1 Volumi 3 Discografia 3.1 Album in studio 3.2…

American high school (1998-) Boston Arts AcademySchool buildingAddress11 Charles St.Boston, Massachusetts 02122United StatesInformationSchool typePublic high schoolFounded1998School districtBoston Public SchoolsDeanTyrone Sutton, Arts Dean Joy Bautista, Academic DeanHeadmasterAnne R. ClarkGrades9-12Enrollment437 (2015-16)[1]Classes offeredAcademics, The ArtsHours in school day8AffiliationsProArts ConsortiumWebsitebostonartsacademy.org Boston Arts Academy (BAA) in Boston, Massachusetts, U…

Scottish classical scholar and epigraphist (1857–1921) William Roger PatonBorn9 February 1857Old Machar, Aberdeen, ScotlandDied21 April 1921 (aged 64)Vathy, Samos, GreeceAlma materOxford UniversityKnown forTranslating the Greek AnthologySignature Title page of the first volume of Paton's prose translation of the Greek Anthology, 1927 William Roger Paton, usually cited as W. R. Paton (9 February 1857 – 21 April 1921),[1] was a Scottish[2][3][4] author…