DNAJC10

DNAJC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3APO, 3APQ, 3APS
Identifiers
Aliases	DNAJC10, ERdj5, JPDI, MTHr, PDIA19, DnaJ heat shock protein family (Hsp40) member C10
External IDs	OMIM: 607987; MGI: 1914111; HomoloGene: 10358; GeneCards: DNAJC10; OMA:DNAJC10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.1 Start 182,716,255 bp[1] End 182,794,464 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 80,145,810 bp[2] End 80,184,387 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis right uterine tube bronchial epithelial cell stromal cell of endometrium tail of epididymis Achilles tendon caput epididymis seminal vesicula mucosa of paranasal sinus islet of Langerhans Top expressed in spermatocyte seminal vesicula spermatid medullary collecting duct renal corpuscle ureter pyloric antrum calvaria tail of embryo Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding misfolded protein binding Hsp70 protein binding protein binding oxidoreductase activity chaperone binding ATPase activator activity disulfide oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor protein-disulfide reductase activity Cellular component membrane endoplasmic reticulum chaperone complex endoplasmic reticulum lumen endoplasmic reticulum Biological process negative regulation of protein phosphorylation cell redox homeostasis response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ubiquitin-dependent ERAD pathway positive regulation of ATP-dependent activity protein folding in endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54431 66861 Ensembl ENSG00000077232 ENSMUSG00000027006 UniProt Q8IXB1 Q9DC23 RefSeq (mRNA) NM_001271581 NM_018981 NM_024181 RefSeq (protein) NP_001258510 NP_061854 NP_077143 Location (UCSC) Chr 2: 182.72 – 182.79 Mb Chr 2: 80.15 – 80.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000077232 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027006 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G (Jan 2003). "ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress". J Biol Chem. 278 (2): 1059–66. doi:10.1074/jbc.M206995200. PMID 12411443.
6. Hosoda A, Kimata Y, Tsuru A, Kohno K (Jan 2003). "JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs". J Biol Chem. 278 (4): 2669–76. doi:10.1074/jbc.M208346200. PMID 12446677.
7. "Entrez Gene: DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gu SH, Chen JZ, Ying K, et al. (2004). "Cloning and identification of a novel cDNA which encodes a putative protein with a DnaJ domain and a thioredoxin active motif, human macrothioredoxin". Biochem. Genet. 41 (7–8): 245–53. doi:10.1023/A:1025510502147. PMID 14587667. S2CID 13635128.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse DnaJ homolog subfamily C member 10 (DNAJC10)