DNAJB2

DNAJB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LGW
Identifiers
Aliases	DNAJB2, DSMA5, HSJ-1, HSJ1, HSPF3, CMT2T, DnaJ heat shock protein family (Hsp40) member B2
External IDs	OMIM: 604139; MGI: 1928739; HomoloGene: 4902; GeneCards: DNAJB2; OMA:DNAJB2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,286,898 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,245,692 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 9; ; tibial nerve;
	Top expressed in
	motor neuron; ; lens; ; spermatid; ; neural layer of retina; ; supraoptic nucleus; ; retinal pigment epithelium; ; spermatocyte; ; muscle of thigh; ; aortic valve; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	polyubiquitin modification-dependent protein binding; proteasome binding; chaperone binding; protein binding; ubiquitin protein ligase binding; ATPase activator activity; Hsp70 protein binding; unfolded protein binding; ubiquitin binding; ubiquitin-dependent protein binding;
Cellular component	inclusion body; proteasome complex; cytosol; nucleus; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; intrinsic component of endoplasmic reticulum membrane; nuclear membrane;
Biological process	response to unfolded protein; negative regulation of protein deubiquitination; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway; protein refolding; negative regulation of inclusion body assembly; regulation of protein localization; regulation of protein ubiquitination; negative regulation of protein binding; positive regulation of ATP-dependent activity; proteasome-mediated ubiquitin-dependent protein catabolic process; chaperone-mediated protein folding; regulation of chaperone-mediated protein folding; negative regulation of cell population proliferation; negative regulation of cell growth; neuron cellular homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	3300
	56812
	ENSG00000135924
	ENSMUSG00000026203
	P25686
	Q9QYI5
	NM_006736; NM_001039550
	NM_001159883; NM_001159884; NM_001159885; NM_020266; NM_178055
	NP_001034639; NP_006727
	NP_001153355; NP_001153356; NP_001153357; NP_064662; NP_835156
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135924 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026203 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheetham ME, Brion JP, Anderton BH (Jul 1992). "Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons". Biochem J. 284 ( Pt 2) (Pt 2): 469–76. doi:10.1042/bj2840469. PMC 1132662. PMID 1599432.
^ Chapple JP, Hardcastle AJ, Kurzik-Dumke U, Collier DA, Cheetham ME (Oct 1999). "Assignment of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32→q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids". Cytogenet Cell Genet. 86 (1): 62–3. doi:10.1159/000015411 (inactive 2024-08-01). PMID 10516435. S2CID 46545726.{{cite journal}}: CS1 maint: DOI inactive as of August 2024 (link)
^ "Entrez Gene: DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2".