UBE1L2

UBA6
Identifiers
Aliases	UBA6, E1-L2, MOP-4, UBE1L2, ubiquitin like modifier activating enzyme 6
External IDs	OMIM: 611361; MGI: 1913894; HomoloGene: 10080; GeneCards: UBA6; OMA:UBA6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 67,612,652 bp[1] End 67,701,155 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 86,257,146 bp[2] End 86,320,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte epithelium of nasopharynx Achilles tendon gingival epithelium germinal epithelium mucosa of paranasal sinus endothelial cell ventricular zone corpus callosum oral cavity Top expressed in otic vesicle hand spermatogonium trigeminal ganglion primitive streak superior cervical ganglion otolith organ maxillary prominence utricle pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FAT10 activating enzyme activity nucleotide binding ligase activity protein binding ATP binding ubiquitin-like modifier activating enzyme activity ubiquitin activating enzyme activity Cellular component cytosol cytoplasm Biological process dendritic spine development amygdala development learning hippocampus development ubiquitin-dependent protein catabolic process locomotory behavior protein ubiquitination cellular response to DNA damage stimulus protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55236 231380 Ensembl ENSG00000033178 ENSMUSG00000035898 UniProt A0AVT1 H0Y9U5 Q8C7R4 RefSeq (mRNA) NM_018227 NM_172712 RefSeq (protein) NP_060697 NP_766300 Location (UCSC) Chr 4: 67.61 – 67.7 Mb Chr 5: 86.26 – 86.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000033178 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035898 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem. 282 (32): 23010–4. doi:10.1074/jbc.C700111200. PMID 17580310.
6. "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhu H, Zhou ZM, Huo R, et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai). 36 (3): 227–34. doi:10.1093/abbs/36.3.227. PMID 15202508.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Jin J, Li X, Gygi SP, Harper JW (2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging". Nature. 447 (7148): 1135–8. Bibcode:2007Natur.447.1135J. doi:10.1038/nature05902. PMID 17597759. S2CID 4337767.
• Chiu YH, Sun Q, Chen ZJ (2007). "E1-L2 activates both ubiquitin and FAT10". Mol. Cell. 27 (6): 1014–23. doi:10.1016/j.molcel.2007.08.020. PMID 17889673.