伊匹木單抗

伊匹木單抗
伊匹木單抗的抗原結合片段英语Fragment antigen-binding(藍)與CTLA-4(綠色)結合 。源自PDB5TRU
单克隆抗体
种类完整抗体
目標CTLA-4
臨床資料
读音i pi lim′ ue mab
商品名英语Drug nomenclatureYervoy
其他名稱BMS-734016,[1] MDX-010,[2] MDX-101
AHFS/Drugs.comMonograph
MedlinePlusa611023
核准狀況
懷孕分級
  • : C
给药途径靜脈注射 (IV)
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物半衰期15 days[7]
识别信息
CAS号477202-00-9  ☒N
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
化学信息
化学式C6742H9972N1732O2004S40
摩尔质量148,634.46 g·mol−1

伊匹木單抗INN:ipilimumab)用于治疗黑色素瘤腎癌間皮瘤非小細胞肺癌英语Non-small-cell lung cancer[8] [9]。常与纳武利尤单抗INN:nivolumab)併用[9]。透过静脉緩慢注射[9]

常见副作用包括皮疹、瘙痒、疲倦、腹泻、恶心、发烧、甲状腺问题、呼吸急促、肝炎和腹痛[9]。其他副作用包括可能發生肠道炎、毒性表皮壞死溶解症英语Toxic epidermal necrolysis周邊神經病變[8]。它是一种单克隆抗体,可與CTLA-4結合并阻断它的功能,進而增强T细胞对抗癌的活性[9]

伊匹木單抗于2011年在美国和欧洲取得医疗使用許可[9] [8]

参考文獻

  1. ^ Yervoy, ipilimumab (BMS-734016) - Product Profile - BioCentury. BioCentury Online Intelligence. BioCentury Publications. [11 August 2016]. 
  2. ^ USAN. STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab (新闻稿). American Medical Association (AMA). [2013-01-12]. (原始内容存档于2016-02-23). 
  3. ^ Regulatory Decision Summary for Yervoy. Drug and Health Products Portal. 7 December 2023 [2 April 2024]. 
  4. ^ Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC). (emc). 3 August 2020 [2 October 2020]. 
  5. ^ Yervoy- ipilimumab injection. DailyMed. 13 August 2020 [2 October 2020]. 
  6. ^ Yervoy EPAR. European Medicines Agency (EMA). 17 September 2018 [2 October 2020]. 
  7. ^ Ipilimumab: Uses, Interactions, Mechanism of Action. DrugBank Online. 25 March 2011 [18 September 2024]. 
  8. ^ 8.0 8.1 8.2 Ipilimumab Monograph for Professionals. Drugs.com. [28 November 2021]. (原始内容存档于6 May 2021) (英语). 
  9. ^ 9.0 9.1 9.2 9.3 9.4 9.5 Yervoy. [28 November 2021]. (原始内容存档于28 September 2020). 

外部連結

  • Ipilimumab. NCI Drug Dictionary. National Cancer Institute. 
  • Ipilimumab. National Cancer Institute. 21 April 2011. 

 

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