非拉妥珠单抗 (INN :ficlatuzumab)是一种人源化 单克隆抗体 ,设计用于治疗癌症 。[ 1]
它可与肝细胞生长因子 结合,从而抑制c-MET 受体信号级联。[ 2]
非拉妥珠单抗由AVEO制药公司开发。2012年5月,AVEO公布了一项II期临床试验的结果,该试验比较了吉非替尼 单独使用以及联合非拉妥珠单抗治疗初治亚洲非小细胞肺癌 患者的情况。[ 3]
参考资料
^ Statement On A Nonproprietary Name Adopted By The USAN Council: Ficlatuzumab (PDF) . American Medical Association . [2024-03-12 ] . (原始内容存档 (PDF) 于2012-09-28).
^ Panahi Y, Mohammadzadeh AH, Behnam B, Orafai HM, Jamialahmadi T, Sahebkar A. A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer. Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology 1286 . 2021: 49–64 (57). ISBN 978-3-030-55034-9 . PMID 33725344 . S2CID 232261340 . doi:10.1007/978-3-030-55035-6_3 .
^ AVEO Releases Phase 2 Data , Drug Discovery & Development , May 3, 2012, dddmag.com [June 3, 2012] , (原始内容存档 于2016-03-03)
血管生成素 CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
受體激動劑: Ersofermin
FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )
Palifermin
Repifermin
Sprifermin
Trafermin
FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A
TrkB
受體激動劑: 3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
阿米替林
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-乙酰血清素
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
TDP6
TrkC
VEGF 其他
Additional growth factors: Adrenomedullin
Colony-stimulating factor s (see here instead)
Connective tissue growth factor (CTGF)
Ephrin s (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )
紅血球生成素 (see here instead)
葡萄糖-6-磷酸異構酶 (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
白细胞介素 /T-cell growth factor s (see here instead)
白血病抑制因子 (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
促血小板生成素 (see here instead)
Wnt信号通路
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)