Intoduction: Cytochrome P450 2E1 (CYP2E1) is the enzyme as a part of CYP 450 enzyme families. It acts in phase I metabolism which result in the formation of electrophilic molecule and elevation of reactive oxygen species (ROS). Review: The last is responsible in development of cancer by damaging the protein and DNA, leading to mutation and increase cell proliferation. Nitrosamine as the most carcinogen for nasopharyngeal carcinoma (NPC) is the substrate of this enzyme. This chemical is contained in the salted fish, tobacco smoke, beer, and preserved food such as meat product. Nitrosamine needs CYP2E1 to activate the pro-carcinogen in order to act is carcinogenic effect. Polymorphism of CYP2E1 is associated with higher transcriptional activity and enzyme activity. Conclussion: It means the ability of this enzyme to activate pro-carcinogen of nitrosamine will increase, leading to higher chance to develop cancer, including NPC.
| Published by | Universitas Sumatera Utara |
| Journal Name | International Journal of Nasopharyngeal Carcinoma |
| Contact Phone | - |
| Contact Name | Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K) |
| Contact Email | - |
| Location | Kota medan, Sumatera utara INDONESIA |
| Website | IJNPC| https://talenta.usu.ac.id/IJNPC| |
| ISSN | ISSN : 26569027, EISSN : 26569035, DOI : https://doi.org/10.32734/ijnpc, |
| Core Subject | Health, |
| Meta Subject | Health Professions, Medicine & Pharmacology, |
| Meta Desc | The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management. |
| Penulis | Farhat, Farhat , Daulay, Elvita Rahmi , Chrestella, Jessy |
| Publisher Article | TALENTA PUBLISHER |
| Subtitle Article | INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://talenta.usu.ac.id/IJNP… |
| DOI | https://doi.org/10.32734/ijnpc.v1i0… |
| DOI Number | DOI: 10.32734/ijnpc.v1i03.2063 |
| Download Article [1] | https://talenta.usu.ac.id/IJNPC/article/… |
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