Mannitol-1-phosphate 5-dehydrogenase

mannitol-1-phosphate 5-dehydrogenase
Identifiers
EC no.	1.1.1.17
CAS no.	9028-24-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate + NAD^+ ${\displaystyle \rightleftharpoons }$ D-fructose 6-phosphate + NADH + H^+

Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NAD^+, whereas its 3 products are fructose 6-phosphate, NADH and H^+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD^+ or NADP^+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD^+ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.

See also

• D-Mannitol

References

• Marmur J, Hotchkiss RD (1955). "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214 (1): 383–96. doi:10.1016/S0021-9258(18)70976-9. PMID 14367396.
• Wolfe JB; Kaplan NO (1955). Wolff, Johnb; Kaplan, Nathano (eds.). [46] Hexose phosphate and hexose reductase. Methods Enzymol. Vol. 1. pp. 346–348. doi:10.1016/0076-6879(55)01050-1. ISBN 978-0-12-181801-2.
• Wolfe JB; Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218 (2): 849–869. doi:10.1016/S0021-9258(18)65848-X. PMID 13295236.