The antidiabetic activity test through a mechanism of inhibition of α-glucosidase enzyme was studied against ethanol, n-hexane, ethyl acetate and n-butanol fractions of ethanol extract of Artocarpus altilis (Parkinson) Fosberg (Moraceae) leaves and four flavonoid compounds isolated from ethyl acetate extracts of A. altilis. Ethyl acetate fraction has strongest antidiabetic activity compared to ethanol, n-hexane, and n-butanol fractions with IC50values5.98,6.79, 440.18and14.42μg/mL, respectively. Four flavonoid compounds (1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (AC-31), 2-geranyl-2,3,4,4-tetrahydroxy dihydrochalcone (AC-51), 8-geranyl-4,5,7-trihydroxyflavone (AC-33) andcyclocommunol (AA-3), have been isolated from ethylacetate fraction. AC-31 was the strongest antidiabetic compound compared to AC-51, AC-33 and cyclocommunolwithIC50values are 15.73, 24.41,49.49,and72.20μg/mL. Kineticstudies of AC-31 using Lineweaver-Burk method showed that inhibition mechanism of enzymeα-glucosidase was anon-competitivetype.
| Published by | Universitas Gadjah Mada |
| Journal Name | Indonesian Journal of Chemistry |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kab. sleman, Daerah istimewa yogyakarta INDONESIA |
| Website | ijc| https://journal.ugm.ac.id/index.php/ijc| |
| ISSN | ISSN : 14119420, EISSN : 24601578, DOI : -, |
| Core Subject | Science, Engineering, |
| Meta Subject | Chemical Engineering, Chemistry & Bioengineering, Chemistry, |
| Meta Desc | Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November). |
| Penulis | Lotulung, Puspa Dewi Narrij , Mozef, Tjandrawati , Risdian, Chandra , Darmawan, Akhmad |
| Publisher Article | Universitas Gadjah Mada |
| Subtitle Article | Indonesian Journal of Chemistry Vol 14, No 1 (2014) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | http://journal.ugm.ac.id/ijc/a… |
| DOI | https://doi.org/10.22146/ijc.21261 |
| DOI Number | DOI: 10.22146/ijc.21261 |
| Download Article [1] | http://journal.ugm.ac.id/ijc/article/dow… |
| Download Article [2] | http://download.garuda.ristekdikti.go.id… |
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