Carica pubescens Lenne K. Koch is one of the typical highland crops in Indonesia. This plant can be found in the region of Cangar and Bromo in East Java, as well as the Dieng Plateau, Central Java Wonosobo-Banjarnegara. Morphological, chemical content, and analysis of protein banding pattern of the Carica pubescens has been done, but more about the use of active compounds for pharmaceutical raw materials, in Diabetes Mellitus type 2 have not been studied. One therapeutic approach to lowering blood sugar levels posprandial is to slow down or inhibit the absorption of glucose through inhibition of the carbohydrates hidrolitic enzyme such as α-amylase and α-glucosidase. This study aims to identify antidiabetic compounds in silico. Antidiabetic compounds were analyzed by methods of docking. The results showed that papain and cysteine protease in C. pubescens have better binding affinity to α-amylase and α-glucosidase compared to iridoid glycosides. Papain and cysteine proteases isolated from C. pubescens are potential to be developed as an antidiabetic.
| Published by | Universitas Islam Negeri Maulana Malik Ibrahim Malang |
| Journal Name | El-Hayah : Jurnal Biologi |
| Contact Phone | +62341558933 |
| Contact Name | Ruri Siti Resmisari, M.Si |
| Contact Email | elhayah@uin-malang.ac.id |
| Location | Kota malang, Jawa timur INDONESIA |
| Website | bio| http://ejournal.uin-malang.ac.id/index.php/bio| |
| ISSN | ISSN : 20860064, EISSN : 26570726, DOI : https://doi.org/10.18860/elha, |
| Core Subject | Health, Science, Agriculture, Social, |
| Meta Subject | Agriculture, Biological Sciences & Forestry, Biochemistry, Genetics & Molecular Biology, Environmental Science, Immunology & microbiology, Medicine & Pharmacology, |
| Meta Desc | El-Hayah : Jurnal Biologi, publishes peer-reviewed research and review articles of special importance and broad interest in any area of biology (such as botany, zoology, ecology, microbiology, physiology, nanobiology, marine biology, hydrobiology, neurobiology, genetics, developmental biology, biochemistry, molecular biology, biophysics, and biomedical sciences), as well as covers the special topic on the relationship between science and religion. |
| Penulis | Laily, Ainun Nikmati , Khoiri, Ahmad Nuruddin |
| Publisher Article | Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang |
| Subtitle Article | El-Hayah Jurnal Biologi Vol 5, No 4 (2016): EL-HAYAH (VOL 5, NO 4,Maret 2016) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | http://ejournal.uin-malang.ac.… |
| DOI | https://doi.org/10.18860/elha.v5i4.… |
| DOI Number | DOI: 10.18860/elha.v5i4.3469 |
| Download Article [1] | http://ejournal.uin-malang.ac.id/index.p… |
| Download Article [2] |
Informasi yang terkait dengan IDENTIFIKASI SENYAWA ANTIDIABETES SECARA in Silico PADA Carica pubescens Lenne & K. Koch
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