SULT1C3

SULT1C3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H8K, 2REO
Identifiers
Aliases	SULT1C3, ST1C3, sulfotransferase family 1C member 3
External IDs	OMIM: 617151; MGI: 102928; HomoloGene: 56817; GeneCards: SULT1C3; OMA:SULT1C3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 108,239,968 bp[1] End 108,265,351 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 C|17 28.07 cM Start 54,268,643 bp[2] End 54,297,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle duodenum mucosa of transverse colon rectum gastric mucosa body of stomach mucosa of esophagus kidney prostate human kidney Top expressed in olfactory epithelium retinal pigment epithelium trachea conjunctival fornix zygote secondary oocyte submandibular gland primary oocyte sexually immature organism hippocampal formation More reference expression data BioGPS n/a
Gene ontology Molecular function alcohol sulfotransferase activity aryl sulfotransferase activity sulfotransferase activity transferase activity Cellular component cytoplasm Biological process sulfur compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 442038 20888 Ensembl ENSG00000196228 ENSMUSG00000023943 UniProt Q6IMI6 Q80VR3 RefSeq (mRNA) NM_001008743 NM_001320878 NM_018751 RefSeq (protein) NP_001008743 NP_001307807 NP_061221 Location (UCSC) Chr 2: 108.24 – 108.27 Mb Chr 17: 54.27 – 54.3 Mb PubMed search [3] [4]
Wikidata
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Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.[5][6][7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.[5]

Clinical significance

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.[8]

See also

• Alcohol sulfotransferase

References

1. GRCh38: Ensembl release 89: ENSG00000196228 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023943 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sulfotransferase family".
6. Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.
7. Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.
8. Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sulfotransferase 1C3 (SULT1C3)