MXD4

MXD4
Identifiers
AliasesMXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDsMGI: 104991; HomoloGene: 4712; GeneCards: MXD4; OMA:MXD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006454

NM_010753

RefSeq (protein)

NP_006445

n/a

Location (UCSC)Chr 4: 2.25 – 2.26 MbChr 5: 34.33 – 34.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[5][6]

Function

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123933Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037235Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
  6. ^ a b "Entrez Gene: MXD4 MAX dimerization protein 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Read other articles:

French composer, conductor and teacher (1892–1974) Milhaud redirects here. For the commune in the Gard, see Milhaud, Gard. For other uses, see Milhaud (disambiguation). Darius MilhaudMilhaud in 1923Born(1892-09-04)4 September 1892Marseille, FranceDied22 June 1974(1974-06-22) (aged 81)Geneva, SwitzerlandEducationParis ConservatoryOccupationsComposerConductorAcademic teacherWorksList of compositionsSpouseMadeleine Milhaud MilhaudChildren1 Darius Milhaud (French: [daʁjys mijo]; 4 Se…

Tris Speaker is the all-time leader in doubles, with 792. In baseball, a double is a hit in which the batter advances to second base in one play, without the benefit of a fielding error, advancing to second on a throw to another base, or another runner being put out on a fielder's choice.[1] A batter may also be credited with a ground-rule double when a fair ball, after touching the ground, bounds into the stands or becomes lodged in a fence or scoreboard.[2] Hall of Fame center …

Численность населения республики по данным Росстата составляет 4 003 016[1] чел. (2024). Татарстан занимает 8-е место по численности населения среди субъектов Российской Федерации[2]. Плотность населения — 59,00 чел./км² (2024). Городское население — 76,72[3] % (2022)…

Lingenfeldcomune Lingenfeld – Veduta LocalizzazioneStato Germania Land Renania-Palatinato DistrettoNon presente CircondarioGermersheim TerritorioCoordinate49°15′N 8°21′E / 49.25°N 8.35°E49.25; 8.35 (Lingenfeld)Coordinate: 49°15′N 8°21′E / 49.25°N 8.35°E49.25; 8.35 (Lingenfeld) Altitudine104 m s.l.m. Superficie15,21 km² Abitanti5 431[1] (31-12-2009) Densità357,07 ab./km² Altre informazioniCod. postale67…

У этого термина существуют и другие значения, см. Большая Кокшага (значения).Большая Кокшагалуг.-мар. Кугу Какшан Характеристика Длина 294 км Бассейн 6330 км² Водоток Исток   (Т) (B)    • Местоположение 4,5 км к СВ от с. Кокшага  • Высота ок. 140 м  • Коор…

Kenyan politician HonourableCharles Cheruiyot KeterAustrian Foreign Minister Sebastian Kurz meets Energy Minister Charles Keter in Nairobi, Kenya on 27 October 2016.3rd Cabinet Secretary for DevolutionIn office2021–2022PresidentUhuru KenyattaPreceded byEugene Wamalwa18th Cabinet Secretary for Energy & PetroleumIn office2015–2021PresidentUhuru KenyattaPreceded byKiraitu MurungiSucceeded byMonica Juma2nd SenatorIn office2013–2015Preceded byJames K Arap SoiSucceeded byAaron Ch…

هنودمعلومات عامةنسبة التسمية الهند التعداد الكليالتعداد قرابة 1.21 مليار[1][2]تعداد الهند عام 2011ق. 1.32 مليار[3]تقديرات عام 2017ق. 30.8 مليون[4]مناطق الوجود المميزةبلد الأصل الهند البلد الهند  الهند نيبال 4,000,000[5] الولايات المتحدة 3,982,398[6] الإمارا…

此條目需要补充更多来源。 (2021年7月4日)请协助補充多方面可靠来源以改善这篇条目,无法查证的内容可能會因為异议提出而被移除。致使用者:请搜索一下条目的标题(来源搜索:美国众议院 — 网页、新闻、书籍、学术、图像),以检查网络上是否存在该主题的更多可靠来源(判定指引)。 美國眾議院 United States House of Representatives第118届美国国会众议院徽章 众议院旗帜…

Ancient Roman style of inscription Quadrata redirects here. For the place in ancient Rome, see Roma quadrata. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Roman square capitals – news · newspapers · books · scholar · JSTOR (February 2014) (Learn how and when to remove this message) A drawing and photographed…

Pour les articles homonymes, voir Williams. Ne pas confondre avec Venus Williams, sa sœur aînée, également joueuse de tennis. Serena Williams (épouse Ohanian) Serena Williams à Roland Garros en 2018. Carrière professionnelle 1995 – 2022 Nom de naissance Serena Jameka Williams Pays États-Unis Naissance 26 septembre 1981 (42 ans)Saginaw, Michigan Taille 1,75 m (5′ 9″) Prise de raquette Droitière, revers à deux mains Entraîneurs Richard Williams (père) (1994-2022)Or…

The Venus de Milo has a WHR value of 0.76.[1] Part of a series onHuman body weight General concepts Obesity (Epidemiology) Overweight Underweight Body shape Weight gain Weight loss Gestational weight gain Diet (nutrition) Weight management Overnutrition Childhood obesity (Epidemiology) Medical concepts Adipose tissue Classification of obesity Genetics of obesity Metabolic syndrome (Epidemiology of metabolic syndrome) Metabolically healthy obesity Obesity paradox Set point theory Measurem…

American racing driver Jeff SimmonsNationality AmericanBorn (1976-08-05) August 5, 1976 (age 47)Hartford, Connecticut, U.S.Related toChris Simmons (brother)IRL IndyCar SeriesYears active2004, 2006–2008TeamsMo Nunn RacingPatrick RacingRahal Letterman RacingA. J. Foyt EnterprisesStarts26Wins0Poles0Best finish16th in 2006Previous series2000, 2003–2006, 2008Indy LightsAwards1999Team USA Scholarship Jeff Simmons (born August 5, 1976) is an American former race car driver[1] who compe…

Order of crustaceans For other uses, see Krill (disambiguation). Krill Northern krill (Meganyctiphanes norvegica) Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Arthropoda Class: Malacostraca Superorder: Eucarida Order: EuphausiaceaDana, 1852 Families and genera Euphausiidae Euphausia Dana, 1852 Meganyctiphanes Holt and W. M. Tattersall, 1905 Nematobrachion Calman, 1905 Nematoscelis G. O. Sars, 1883 Nyctiphanes G. O. Sars, 1883 Pseudeuphausia Hansen, 1910 Stylocheiron G. O…

Halaman ini berisi artikel tentang Dreamus. Untuk untuk merek dan divisi pemasaran, lihat iriver. Dreamus CompanyNama asli(주)드림어스컴퍼니SebelumnyaReignCom IriverJenisPublikKode emitenKRX: 060570IndustriElektronik konsumenMusik[1]Didirikan1999; 25 tahun lalu (1999)PendiriDuk-Jun YangKantorpusatIRIVER House, 5 Bangbae-ro 18-gil, Bangbae-dong, Seocho-gu, Seoul, Korea SelatanWilayah operasiSeluruh duniaTokohkunciDuk-Jun Yang (CEO)Pendapatan US$51,649[2] (2015)La…

English colonial administrator Not to be confused with his nephew, Sir William Berkeley (Royal Navy officer). Sir William BerkeleyGovernor of VirginiaIn office1660–1677Appointed byCharles IIPreceded bySamuel MathewsSucceeded bySir Herbert JeffreysIn office1642–1652Appointed byCharles IPreceded bySir Francis WyattSucceeded byRichard Bennett Personal detailsBorn1605Hanworth Manor,Middlesex, EnglandDied9 July 1677(1677-07-09) (aged 71–72)Berkeley House,Mayfair, EnglandResting placeSt Mar…

City in Ontario, Canada This article is about the city in Ontario, Canada. For the indigenous people, see Mississaugas. For the First Nation, see Mississauga First Nation. For the rattlesnake species, see Massasauga. City in Ontario, CanadaMississaugaCity (lower-tier)City of MississaugaFrom top, left to right: Mississauga City Centre, the Mississauga Civic Centre, Health Sciences Complex at the University of Toronto Mississauga, Old Grammar School in Streetsville, the Credit River, 282 Church St…

Узбекистан на Олімпійських іграх Код МОК:UZB НОК:Національний олімпійськийкомітет Узбекистану Олімпійські ігри в Атланті Спортсмени 71 у 12 видах спорту Прапороносець Тимур Ібрагімов МедаліМісце: 58 Золото0 Срібло1 Бронза1 Всього2 Участь у літніх Олімпійських ігра…

10,5 cm Flak 38 Meriam anti-pesawat Flak 38 105 mm di sebuah baterai artileri pesisir, 1942 Jenis Meriam anti-pesawat Negara asal Jerman Nazi Sejarah pemakaian Masa penggunaan 1937–62 Digunakan oleh Jerman Nazi (1937-45), AL Prancis (1953-62) Pada perang Perang Dunia II Sejarah produksi Perancang Rheinmetall Tahun 1933 Produsen Rheinmetall Diproduksi 1936–45 Jumlah produksi Sekitar 4.200 Spesifikasi (Flak 39) Berat 10.224 kg (22,540 lbs) Panjang 6.648 …

Two-pronged implement resembling a pitchfork Pluto holding a bident in a woodcut from the Gods and Goddesses series of Hendrick Goltzius (1588–1589) A bident is a two-pronged implement resembling a pitchfork. In Greek mythology, the bident is a weapon associated with Hades (Pluto), the ruler of the underworld. Likewise, the three-pronged trident is the implement of his brother Poseidon (Neptune), god of the seas and earthquakes, while the lightning bolt, which superficially appears to have a s…

杨格非来华传教士出生1831年12月14日南威尔士斯温西逝世1912年7月25日英格兰倫敦 杨格非(英語:Griffith John,直译:格里菲斯·约翰,1831年—1912年),又译杨约翰、杨笃信,英国伦敦会著名的来华传教士之一,中国华中地区基督教事业的开创者。 1831年12月14日,杨格非出生于英国威尔士斯温西一个公理会基督徒的家庭,家境比较贫穷。在8岁时被公理会教堂接纳为正式成员,14…