TAL2

TAL2
Identifiers
Aliases	TAL2, TAL bHLH transcription factor 2
External IDs	OMIM: 186855; MGI: 99540; HomoloGene: 3954; GeneCards: TAL2; OMA:TAL2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.2 Start 105,662,457 bp[1] End 105,663,124 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B2|4 28.75 cM Start 53,779,705 bp[2] End 53,788,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii vastus lateralis muscle buccal mucosa cell muscle of thigh deltoid muscle renal medulla ganglionic eminence ventricular zone gastrocnemius muscle Top expressed in pineal gland embryo granulocyte temporal muscle spermatid hair follicle seminiferous tubule muscle of thigh skeletal muscle tissue esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated post-embryonic development transcription, DNA-templated midbrain development multicellular organism growth thalamus development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6887 21350 Ensembl ENSG00000186051 ENSMUSG00000028417 UniProt Q16559 Q62282 RefSeq (mRNA) NM_005421 NM_009317 RefSeq (protein) NP_005412 NP_033343 Location (UCSC) Chr 9: 105.66 – 105.66 Mb Chr 4: 53.78 – 53.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[5][6]

Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.[7]

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[6][8]

References

1. GRCh38: Ensembl release 89: ENSG00000186051 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028417 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
6. Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
7. Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
8. Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity". Oncogene. 9 (5): 1437–46. PMID 8152805.
• Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.