The road that today constitutes the street was laid by Francisco Pizarro when he founded the city of Lima on January 18, 1535. In 1862, when a new urban nomenclature was adopted, the road was named jirón Cuzco, after the department of Cuzco. Prior to this renaming, each block (cuadra) had a unique name:
Block 1: Espalda de la Pileta de la Merced, after the fountain of the convent of the same name.[1]
Block 2: Higuera, after either the fig trees or one of the families of the same name.[2]
Block 3: Trinidad, after the convent of the same name.[3]
Block 6: Zamudio, after the Zamudio de las Infantas family, who lived there.[6] Alternatively, it was known as the Callejón del Gigante, after Juan Núñez, a Huamanga-born mestizo known for his large height.[7]
Block 7: San Pedro Nolasco, after the school and convent of the same name.[8] Alternatively known as Llanis, for reasons unknown.[9]
Block 8: Granados, after either the pomegranate trees or one of the families of the same name.[10]
Block 9: Tobal, after the tuff (toba) that had formed on the street.[11]
Block 10: Pampa de Lara, after the family of the same name.[12]