HLA-B75

Further information: HLA-serotype tutorial
Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B75
Alleles B*1513
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]

B75 is one of many split antigens of the broad antigen, B15. B75 (B*1502) is associated with a severe drug-induced skin condition in ethnic East Asians.[2]

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA-B*15 gene products[3]
B*15 B15 B62 B63 B70 B71 B72 B75 B76 B77 Sample
allele % % % % % % % % % size (N)
*1502 7 22 62 1035
*1521 7 12 55 132
Alleles link-out to IMGT/HLA Database at EBI

Alleles

HLA B*1502 frequencies
freq
ref. Population (%)
[4] Philippines Ivatan 22.0
Taiwan Puyuma 18.0
China Guangxi Maonan 14.8
China Yunnan Lisu 12.3
Taiwan Tao 12.0
Singapore Chinese Han 11.6
China Guangzhou 11.0
Hong Kong Chinese 10.2
China Yunnan Nu 9.0
Singapore Riau Malay 8.4
Singapore Javanese Indonesians 8.2
Thailand (3) 8.2
China South Han 7.1
Singapore Thai 6.1
India Khandesh Pawra 6.0
Taiwan Minnan pop 1 5.9
Singapore Chinese 5.7
India West Bhils 4.0
Taiwan Pazeh 3.6
China Guangdong Meizhou Han 3.5
South Africa Natal Tamil 3.1
China Qinghai Hui 2.7
Taiwan Hakka 2.7
Shijiazhuang Tianjian Han 2.4
China North Han 1.9
India Mumbai Marathas 1.9
India North Delhi 1.6
China Beijing 1.5
China Inner Mongolia 1.5
American Samoa 1.0
India North Hindus 1.0
Taiwan Siraya 1.0
Taiwan Tsou 1.0
Ingig. Australian Groote Eylandt 0.7
United Arab Emirates 0.6
HLA B*1521 frequencies
freq
ref. Population (%)
[4] Indig. Australian Cape York Penin. 13.5
Indig. Australian Yuendumu 12.4
PNG Eastern Highlands Goroka 7.1
Ind. Australian Groote Eylandt 6.0
New Caledonia 5.8
Singapore Riau Malay 4.0
American Samoa 3.0
Australian Aborigine Kimberly 2.6
PNG Karimui Plateau 2.5
Singapore Javanese Indonesians 2.0
Papua New Guinea Wanigela 1.5
USA Asian 1.4
Philippines Ivatan 1.0
Thailand (3) 1.0
Taiwan Hakka 0.9

Diseases

HLA-B*1502 is associated with carbamazepine and phenytoin–induced Stevens–Johnson syndrome in Chinese and Thai people.[2][5][6] One study showed a 100% association between B*1502 and the drug-induced skin disorder in a Chinese population.[5] In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol.[citation needed]

References

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ a b Chung WH, Hung SI, Hong HS, et al. (April 2004). "Medical genetics: a marker for Stevens–Johnson syndrome". Nature. 428 (6982): 486. Bibcode:2004Natur.428..486C. doi:10.1038/428486a. PMID 15057820.
  3. ^ derived from IMGT/HLA
  4. ^ a b Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
  5. ^ a b Locharernkul C, Loplumlert J, Limotai C, et al. (July 2008). "Carbamazepine and phenytoin induced Stevens–Johnson syndrome is associated with HLA-B*1502 allele in Thai population". Epilepsia. 49 (12): 2087–91. doi:10.1111/j.1528-1167.2008.01719.x. PMID 18637831. S2CID 23063530.
  6. ^ Man CB, Kwan P, Baum L, et al. (May 2007). "Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese". Epilepsia. 48 (5): 1015–8. doi:10.1111/j.1528-1167.2007.01022.x. PMID 17509004.