Human leukocyte antigen serotype
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B58
Alleles
*5801, *5802
Structure (See HLA-B )
Shared data
Locus
chr.6 6p21.31
HLA-B58 (B58) is an HLA -B serotype . B58 is a split antigen from the B17 broad antigen , the sister serotype B57 .[ 1] [ 2] HLA-serotype tutorial ) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.
Serotype
B58 and B17 serotype recognition of some more common HLA B*58 alleles[ 3]
B*58
B58
B17
Sample
allele
%
%
size (N)
*5801
79
4
2096
*5802
72
3
837
Allele distribution
HLA B*5801 frequencies
freq
ref.
Population
(%)
[ 4] Cameroon Pygmy Baka
15.0
[ 4] India Khandesh Pawra
15.0
[ 4] Cameroon Sawa
11.5
[ 4] Taiwan Hakka
10.9
[ 4] Kenya Nandi
10.0
[ 4] India West Bhils
9.0
[ 4] China South Han
8.9
[ 4] China Inner Mongolia
8.8
[ 4] India North Delhi
8.8
[ 4] Thailand Northeast
8.4
[ 4] Guinea Bissau
7.8
[ 4] Thailand
7.7
[ 4] India Mumbai Marathas
7.4
[ 4] India Andhra Pradesh Golla
7.2
[ 4] Kenya Luo
7.0
[ 4] Senegal Niokholo Mandenka
6.9
[ 4] India New Delhi
6.8
[ 4] Oman
6.8
[ 4] Russia Tuva (2)
6.7
[ 4] South Korea (3)
6.5
[ 4] Italy Sardinia (3)
6.4
[ 4] Burkina Faso Fulani
6.1
[ 4] Taiwan Siraya
5.9
[ 4] India North Hindus
5.8
[ 4] Burkina Faso Mossi
5.7
[ 4] Cameroon Yaounde
5.4
[ 4] Cameroon Bamileke
5.2
[ 4] Singapore Riau Malay
5.0
[ 4] Saudi Arabia Guraiat and Hail
4.6
[ 4] France Corsica
4.5
[ 4] Sudanese
4.5
[ 4] Zimbabwe Harare Shona
4.4
[ 4] Burkina Faso Rimaibe
4.3
[ 4] Iran Baloch
4.0
[ 4] South African Natal Zulu
4.0
[ 4] Tunisia
4.0
[ 4] Uganda Kampala
4.0
[ 4] Cameroon Beti
3.7
[ 4] Tunisia Ghannouch
3.7
[ 4] Taiwan Pazeh
3.6
[ 4] Tunisia Tunis
3.4
[ 4] Italy North (1)
3.3
[ 4] Israel Ashkenazi and Non Ashkenazi Jews
3.2
[ 4] India West Coast Parsis
3.0
[ 4] China North Han
2.9
[ 4] Ivory Coast Akan Adiopodoume
2.3
[ 4] Mali Bandiagara
2.2
[ 4] Mexico Zaptotec Oaxaca
2.2
[ 4] South Africa Natal Tamil
2.0
[ 4] China Yunnan Nu
1.9
[ 4] Bulgaria
1.8
[ 4] China Tibet Autonomous Region Tibetans
1.6
[ 4] France South East
1.6
[ 4] Israel Arab Druse
1.5
[ 4] Czech Republic
1.4
[ 4] Georgia Tbilisi Georgians
1.4
[ 4] Jordan Amman
1.4
[ 4] Morocco Nador Metalsa (berber)
1.4
[ 4] Croatia
1.3
[ 4] Romanian
1.3
[ 4] Spain Eastern Andalusia
1.2
[ 4] Australian Aborigine Cape York Peninsula
1.0
B*5802
[ 4] Cameroon Bamileke
14.3
[ 4] Kenya Luo
12.5
[ 4] Cameroon Yaounde
10.9
[ 4] Cameroon Pygmy Baka
10.0
[ 4] Cameroon Beti
9.8
[ 4] Kenya Nandi
8.5
[ 4] South African Natal Zulu
8.5
[ 4] Cameroon Sawa
7.7
[ 4] Zimbabwe Harare Shona
6.4
[ 4] Cape Verde Northwestern Islands
5.6
[ 4] Uganda Kampala
4.4
[ 4] Central Africa Republic Mbenzele Pygmy
4.0
[ 4] Zambia Lusaka
2.3
[ 4] Iran Baloch
1.0
[ 4] Tunisia
1.0
Disease
HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome .[ 5] [ 6] [ 7] [ 8]
References
^ Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58" . J. Biol. Chem . 260 (22): 11924– 33. doi :10.1016/S0021-9258(17)38967-6 PMID 2995352 . ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010" . Tissue Antigens . 75 (4): 291– 455. doi :10.1111/j.1399-0039.2010.01466.x . PMC 2848993 PMID 20356336 . ^ derived from IMGT/HLA ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database" . Tissue Antigens . 61 (5): 403– 7. doi :10.1034/j.1399-0039.2003.00062.x PMID 12753660 . ^ Chung WH, Hung SI, Chen YT (August 2007). "Human leukocyte antigens and drug hypersensitivity". Curr Opin Allergy Clin Immunol . 7 (4): 317– 23. doi :10.1097/ACI.0b013e3282370c5f . PMID 17620823 . S2CID 31415054 . ^ Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W (2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population". Pharmacogenet Genomics . 19 (9): 704– 9. doi :10.1097/FPC.0b013e328330a3b8 . PMID 19696695 . S2CID 24941838 . ^ Hung SI, Chung WH, Liou LB, et al. (March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol" . Proc. Natl. Acad. Sci. U.S.A . 102 (11): 4134– 9. Bibcode :2005PNAS..102.4134H . doi :10.1073/pnas.0409500102 PMC 554812 PMID 15743917 . ^ Lonjou C, Borot N, Sekula P, et al. (February 2008). "A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs". Pharmacogenet. Genomics . 18 (2): 99– 107. doi :10.1097/FPC.0b013e3282f3ef9c . PMID 18192896 . S2CID 35512622 .
