HLA-B59

major histocompatibility complex (human), class I, B59
Alleles B*5901
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5901
Locus chr.6 6p21.31

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products.[1] B59 is a hybrid between B*55 and B*51.[2] B59 is more common in Japan, Korea, N. China and Mongolia. (For terminology help see: HLA-serotype tutorial)

Serotype

B59 serotype recognition of the HLA B*59 allele-group gene products[3]
B*59 B59 Other Sample
allele % % size (N)
5901 45 41 123

B*5901 allele frequencies

HLA B*5901 frequencies
freq
ref. Population (%)
[4] Okinawan (USA Hawaii) 6.3
[4] Japan (2) 2.7
[4] Tarialan Khoton (Mongolia) 2.4
[4] South Korea (3) 2.1
[4] Gipuscoa Basque (Spain) 2.0
[4] Japan Central 1.8
[4] Casablanca (Morocco) 1.8
[4] Hyogo (Japan) 1.6
[4] N. Korean (Harbin, China) 1.0
[4] Manchu (Harbin, China) 0.6
[4] Naxi (Yunnan, China) 0.6
[4] Girona (Catalonia, Spain) 0.6
[4] Algeria (1) 0.5
[4] Inner Mongolia (China) 0.5
[4] Khalkha (Mongolia) 0.5
[4] Shanghai (China) 0.3
[4] Essen (German ) 0.3
[4] Southern Han (China) 0.2
[4] Shij. Tian. (Beijing, China) 0.1
[4] Hakka (Taiwan) 0.1
Regions of higher B*5901 frequency
Japan
Korea
Mongolia
Heilongjiang
prov., China
(Harbin city)

References

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Hildebrand WH, Domena JD, Parham P (1993). "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, and not a subtype of HLA-B8". Tissue Antigens. 41 (4): 190–5. doi:10.1111/j.1399-0039.1993.tb02001.x. PMID 8362411.
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.