HLA-B35

Computer illustration of HLA-B*3508 with EBV (EPLPQGQLTAY) in the binding pocket.
B*3508-β2MG with bound peptide
2h6p​
major histocompatibility complex (human), class I, B35
Alleles B*3501, 3502, 3503, . . .
Structure (See HLA-B)
Symbol(s) HLA-B 2fyy​, 2fz3​
EBI-HLA B*3501 2h6p​, 2cik​,
1a1n​
EBI-HLA B*3502
EBI-HLA B*3503
EBI-HLA B*3504
EBI-HLA B*3505
EBI-HLA B*3506
EBI-HLA B*3507
EBI-HLA B*3508 2nw3​, 2nx5​
EBI-HLA B*3509
EBI-HLA B*3510
EBI-HLA B*3511
EBI-HLA B*3512
Locus chr.6 6p21.31

HLA-B35 (B35) is an HLA-B serotype. The serotype identifies the more common HLA-B*35 gene products.[1] B35 is one of the largest B serotype groups, it currently has 97 known nucleotide variants and 86 polypeptide isoforms. (For terminology help see: HLA-serotype tutorial). This variant is particularly susceptible to HIV infection.

Serotype

B35 serotype recognition of Some HLA B*35 allele-group gene products[2]
B*35 B35 Sample
allele % % size (N)
3501 98 2023
3502 72 1013
3503 94 1226
3504 100 26
3505 94 231
3506 79 10
3508 91 349
3509 68 3
3510 75 12
3511 67 17
3512 78 422
3514 79 29
3520 42 23

References

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ derived from IMGT/HLA