HEPPS
HEPPS
Names
Preferred IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
HEPPS, EPPS
Identifiers
ChEBI
ChemSpider
ECHA InfoCard
100.036.528
UNII
InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
Y Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N
Y InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
Key: OWXMKDGYPWMGEB-UHFFFAOYAP
O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
C 9 H 20 N 2 O 4 S
Molar mass
252.33 g·mol−1
Melting point
(decomposes)
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
HEPPS (EPPS ) is a buffering agent used in biology and biochemistry . The pKa of HEPPS is 8.00. It is ones of Good's buffers .[ 1]
Research on mice with Alzheimer's disease -like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[ 2] [ 3] [ 4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease .[ 5] [ 6] [ 7]
See also
References
^ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry . 5 (2): 467– 77. doi :10.1021/bi00866a011 . PMID 5942950 .
^ "Small Molecule Breaks Up Amyloid Aggregates In Mice" . Chemical & Engineering News . Retrieved 14 December 2015 .
^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques" . Nature Communications . 6 : 8997. Bibcode :2015NatCo...6.8997K . doi :10.1038/ncomms9997 . PMC 4686862 . PMID 26646366 .
^ "Chemical clears Alzheimer's protein and restores memory in mice" . MedicalXpress. Retrieved December 10, 2015 .
^ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system" . Science Advances . 5 (4): eaav1388. Bibcode :2019SciA....5.1388K . doi :10.1126/sciadv.aav1388 . ISSN 2375-2548 . PMC 6469948 . PMID 31001580 .
^ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined" . Analysis & Separations from Technology Networks . Retrieved 2019-09-30 .
^ "A possible blood test for early-stage Alzheimer's disease" . medicalxpress.com . Retrieved 2019-09-30 .
Simple piperazines(no additional rings) Phenylpiperazines
2C-B-PP
3,4-CFP
Acaprazine
Antrafenine
Aripiprazole
Batoprazine
Bifeprunox
BRL-15,572
Ciprofloxacin
CSP-2503
Dapiprazole
DCPP
DMPP
Diphenylpiperazine
Dropropizine
EGIS-12,233
Elopiprazole
Eltoprazine
Enpiprazole
Ensaculin
Etoperidone
Flesinoxan
Fluanisone
Flibanserin
Fluprazine
Itraconazole
Ketoconazole
Levodropropizine
Lorpiprazole
mCPP
Mefway
MeOPP
Mepiprazole
Naftopidil
Naluzotan
Naphthylpiperazine
Nefazodone
Niaprazine
Oxypertine
Pardoprunox
pCPP
pFPP
Posaconazole
S-14,506
S-14,671
S-15,535
SB-258,585
SB-271,046
SB-357,134
SB-399,885
Sonepiprazole
TFMPP
Tolpiprazole
Trazodone
Urapidil
Vesnarinone
Vilazodone
Vortioxetine
WAY-100,135
WAY-100,635
Benzylpiperazines Diphenylalkylpiperazines (benzhydrylalkylpiperazines) Pyrimidinylpiperazines Pyridinylpiperazines Benzo(iso)thiazolyl piperazines Tricyclics (piperazine attached via side chain) Others/Uncategorized