Estrobin

Estrobin

Clinical data
ATC code	None
Identifiers
IUPAC name 1,1'-(2-Bromo-2-phenyl-1,1-ethenediyl)bis(4-ethoxybenzene)
CAS Number	60883-74-1^Y
PubChem CID	109030
ChemSpider	98048
UNII	MM7V5ZUU9B
CompTox Dashboard (EPA)	DTXSID30209726
Chemical and physical data
Formula	C24H23BrO2
Molar mass	423.350 g·mol^−1

Estrobin, also known as α,α-di(p-ethoxyphenyl)-β-phenylbromoethylene and commonly abbreviated as DBE, is a synthetic, nonsteroidal estrogen of the triphenylethylene group that was never marketed.[1][2] Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it.[1][2] Estrobin, similarly to other triphenylethylenes, is very lipophilic and hence very long-lasting in its duration of action.[1][2] Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body.[2]

See also

• Broparestrol
• Diethylstilbestrol
• M2613
• Stilbestrol
• Ethamoxytriphetol
• 2,8-DHHHC

References

1. Jordan VC (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 23–. ISBN 978-0-299-10480-1.
2. Welsh AL (April 1954). "Use of synthetic estrogenic substance chlorotrianisene (TACE) in treatment of acne". Archives of Dermatology. 69 (4): 418–27. doi:10.1001/archderm.1954.01540160020004. PMID 13147544.