Santomero worked as a researcher for Nickelodeon in the early 1990s,[10] when the network was looking to create a new television show for preschoolers. In 1994, Santomero, along with director Todd Kessler and animator Traci Paige Johnson (a group that Nickelodeon executive Brown Johnson called a "green creative team"[11]), created the "landmark"[6] series Blue's Clues. According to writer Diane Tracy, Santomero, Kessler, and Johnson did not possess traditional backgrounds of most producers of children's programs, but "did possess an amazing combination of talents, backgrounds, and personal attributes."[12] Santomero served as executive producer and head writer, and designed the show's research and curriculum. She produced and developed other Blue's Clues projects, such as the full-length movie Blue's Big Musical Movie, educational CDs and books based on the show, two Blue's Clues theatrical productions, which toured across the U.S., and the reboot Blue's Clues & You!.[6] She was also the founder of a company called Out of the Blue Enterprises which later was renamed to 9 Story USA. In 2007, Santomero created the PBS program Super Why!; she also served as executive producer and head writer.[6]
In 2011, she became host of PBS's The Parent Show, an online series about parenting. In September 2012, Daniel Tiger's Neighborhood, for which Santomero is creator,[13] executive producer and head writer, debuted on PBS.[14] After Fred died in 2003, "Kevin Morrison (CEO-Fred Rogers Co.) reached out to Angela and asked what show she would do to honor Fred's legacy". Her idea was an animated version of Fred Rogers' Neighborhood of Make Believe. This was the birth of Daniel Tiger's Neighborhood.[15]
On March 28, 2023, Angela C. Santomero left 9 Story Media Group as Chief Creative Officer, but she will still be working at 9 Story USA as the CEO.
^Albrizio, Lianna. "Harrington Park school district honors Blues Clues writer", Northern Valley Suburbanite, July 7, 2011. accessed April 22, 2013. "And on June 20, the k-8 school recognized Angela C. Santomero, co-writer of the Emmy award-winning children's television show, Blues Clues, as the latest Circle of Leadership inductee during the school's moving up ceremony.... A member of the class of 1982, Santomero is someone who Fried feels embodies this idea."
^Nathan, Bradi. "Meet Blue's Clues and Super WHY! creator, Angela Santomero"Archived June 14, 2013, at the Wayback Machine, MyWorkButterfly.com, August 3, 2010. Accessed April 22, 2013. "Four towns poured into Northern Valley Regional High School in Old Tappan New Jersey. There couldn't have been more than 5,000 people in each town. Harrington Park was one of them- a sleepy little area in Bergen County that I called home.... I fondly remember two sisters who lived in Harrington Park: Jennifer and Angela.... Amongst her many accomplishments, Angela led the production and development of the Emmy nominated Blue's Big Musical Movie, wrote two Blue's Clues' theatrical productions that played in venues across the nation and co-founded Out of the Blue Enterprises."
