The 2021–22 season was the 91st season in the existence of CA Osasuna and the club's third consecutive season in the top flight of Spanish football. In addition to the domestic league, Osasuna participated in this season's edition of the Copa del Rey.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: LaLiga Santander Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Fair-play points (Note: Head-to-head record is used only after all the matches between the teams in question have been played)[14] Notes:
^Sebastián, Joel; Velasco, Gonzalo (1 February 2021). "Jonas Ramalho, cedido a Osasuna" [Jonas Ramalho, loaned to Osasuna]. Marca (in Spanish). Retrieved 2 February 2021.