The 2021–22 season was the 27th season in the existence of FC Cartagena and the club's second consecutive season in the second division of Spanish football. In addition to the domestic league, Cartagena participated in this season's edition of the Copa del Rey.
Players
First-team squad
As of 22 March 2022
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Stadium: Cartagonova Referee: Pablo González Fuertes
Notes
^Racing Rioja played its game at Las Gaunas, in Logroño instead of their regular stadium El Salvador as it does not meet the requirements established by the Royal Spanish Football Federation.