孕烷醇酮
此條目介紹的是孕酮的3α,5β-还原产物。关于孕烷醇酮的其它立体异构体,请见「 孕烷醇酮 (消歧义)」。
孕烷醇酮
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IUPAC名 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
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别名
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Eltanolone; 5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; 3α,5β-Tetrahydroprogesterone; 3α,5β-THP; 3α-Hydroxy-5β-tetrahydroprogesterone
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识别
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CAS号
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128-20-1
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PubChem
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31402
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ChemSpider
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29132
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SMILES
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- CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C
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InChI
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- 1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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InChIKey
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AURFZBICLPNKBZ-YZRLXODZBF
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ChEBI
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1712
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性质
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化学式
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C21H34O2
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摩尔质量
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318.49 g·mol−1
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药理学
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给药途径
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Intravenous injection[1]
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药代动力学:
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0.9–3.5 hours[1][2][3]
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若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。
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孕烷醇酮(英語:Pregnanolone,也名为3α,5β-孕烷醇酮)也被称为乙他诺隆(英語:eltanolone)是一种内源性的抑制性神经甾体,在体内由孕酮合成而来[4],和其异构体别孕烷醇酮有着类似的性质[4]。
参考文献
- ^ 1.0 1.1 Carl P, Høgskilde S, Lang-Jensen T, et al. Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol Scand. October 1994, 38 (7): 734–41. PMID 7839787. doi:10.1111/j.1399-6576.1994.tb03987.x.
- ^ Gray HS, Holt BL, Whitaker DK, Eadsforth P. Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia. Br J Anaesth. March 1992, 68 (3): 272–6. PMID 1547051. doi:10.1093/bja/68.3.272.
- ^ Carl P, Høgskilde S, Nielsen JW, Sørensen MB, Lindholm M, Karlen B, Bäckstrøm T. Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. Anaesthesia. March 1990, 45 (3): 189–97. PMID 2334030. doi:10.1111/j.1365-2044.1990.tb14683.x.
- ^ 4.0 4.1 Reddy DS. Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol. 2003, 15 (3–4): 197–234. PMID 15248811. doi:10.1615/critrevneurobiol.v15.i34.20.
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