Pakoba as an endemic plant in North Sulawesi has ethnomedical benefits in treating diabetes. The purpose of this study was to determine the histopathological of pancreatic hyperglycemic rats induced by alloxan by the administration of pakoba stem bark ethanol extract (PSBEE). Rats with an average weight of 150-200 gr were divided into 5 treatment groups. Group I as a normal control without alloxan administration then group II alloxan control, group III were treated with glibenclamide 5 mg/kgbw, groups IV and V were treated with PSBEE 150 and 300 mg/kgbw oral gavage. Phytochemical screening results of PSBEE contain a lot of alkaloids, flavonoids, and tannins. A dose of 300 mg/kgbw PSBEE is better in repair pancreatic cells in hyperglycemia rats compared with a dose of 150 mg/kgbw. There needs further research to know the antioxidant activity, the mechanism of the active compound content of the pakoba stem bark as an antihyperglycemic.
| Published by | Universitas Jenderal Soedirman |
| Journal Name | Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kab. banyumas, Jawa tengah INDONESIA |
| Website | biosfera| https://journal.bio.unsoed.ac.id/index.php/biosfera| |
| ISSN | ISSN : 08531629, EISSN : 08531629, DOI : -, |
| Core Subject | Science, Agriculture, Social, |
| Meta Subject | Agriculture, Biological Sciences & Forestry, Biochemistry, Genetics & Molecular Biology, Environmental Science, |
| Meta Desc | Majalah Ilmiah Biologi Biosfera : A Scientific Journal merupakan peer reviewed jurnal yang diterbitkan oleh Fakultas Biologi Universitas Jenderal Soedirman. Media ini mewadahi hasil-hasil penelitian di bidang biologi tropika yang terbit tiga kali setahun (Januari, Mei, September). |
| Penulis | Walean, Mario , Melpin, Rostina , Rondonuwu, Mervina , Pinontoan, Kinzie Feliciano |
| Publisher Article | Fakultas Biologi | Universitas Jenderal Soedirman |
| Subtitle Article | Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 37, No 1 (2020) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://journal.bio.unsoed.ac.… |
| DOI | https://doi.org/10.20884/1.mib.2020… |
| DOI Number | DOI: 10.20884/1.mib.2020.37.1.1210 |
| Download Article [1] | https://journal.bio.unsoed.ac.id/index.p… |
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