The research of Immunoglobulin M (IgM) activity of Theobroma cacao peel extract has been done to 20 rats. The parameter is agglutination between serum of rats and antigen. Rats were grouped to 4 group, which are group of negative control and 3 groups as experiment groups those given by extract in 250, 500 and 700 mg doses of rats. On the first day was given SDMK 2% by Intraperitonial and after 5 day the serum taken and tested. The data of agglutination then analyzed by Anova. The experiment showed that Theobroma cacao peel extract has activity as immunostimulant in 500 mg doses of rats effective dose. Keywords: Theobroma cacao peel extract, agglutination, immunostimulant, Immunoglobulin M (IgM) ABSTRAK Penelitian Aktivitas Imunoglobulin M (IgM) Ekstrak Kulit Buah Kakao (Theobroma cacao L.) telah dilakukan terhadap 20 ekor tikus uji. Parameter yang diamati adalah terjadinya aglutinasi antara serum tikus yang telah diberi perlakuan dengan antigen. Tikus putih dikelompokkan menjadi 4 kelompok yaitu kelompok kontrol negatif diberi Na CMC 0,5%, serta 3 kelompok uji yang diberikan ekstrak dengan konsentrasi 250, 500 dan 700 mg/200 g BB Tikus. Perlakuan secara per oral diberikan selama 5 hari. Pada hari ke-1 diinjeksikan Sel Darah Merah Kambing (SDMK) 2% secara intraperitonial dan setelah perlakuan, yaitu hari ke-7 serum diambil dan dilakukan pengujian dengan metode titer antibodi. Data hasil pengamatan aglutinasi di analisis menggunakan Anova. Hasil penelitian menunjukkan bahwa ekstrak kulit buah Kakao memiliki aktivitas sebagai imunostimulan dengan dosis terbaik 500 mg/200 g BB tikus. Kata kunci: Ekstrak Kulit Buah Kakao, Theobroma cacao L., IgM tikus putih, Hemaglutinasi, Imunostimulan
| Published by | Universitas Mulawarman |
| Journal Name | Journal of Tropical Pharmacy and Chemistry |
| Contact Phone | - |
| Contact Name | Hadi kuncoro |
| Contact Email | kuncoro_hadi82@yahoo.com |
| Location | Kota samarinda, Kalimantan timur INDONESIA |
| Website | jtpc| https://jtpc.farmasi.unmul.ac.id/index.php/jtpc| |
| ISSN | ISSN : 20877099, EISSN : 24076090, DOI : -, |
| Core Subject | Health, Science, Agriculture, Engineering, |
| Meta Subject | Agriculture, Biological Sciences & Forestry, Biochemistry, Genetics & Molecular Biology, Chemical Engineering, Chemistry & Bioengineering, Medicine & Pharmacology, Public Health, |
| Meta Desc | Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English. |
| Penulis | Siregar, Vita Olivia , Rusli, Rolan , Ibrahim, Arsyik |
| Publisher Article | Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117 |
| Subtitle Article | Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://jtpc.farmasi.unmul.ac.… |
| DOI | https://doi.org/10.25026/jtpc.v2i5.… |
| DOI Number | DOI: 10.25026/jtpc.v2i5.74 |
| Download Article [1] | https://jtpc.farmasi.unmul.ac.id/index.p… |
| Download Article [2] | http://download.garuda.ristekdikti.go.id… |
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