WFIKKN2

WFIKKN2
Identifiers
Aliases	WFIKKN2, GASP-1, WFDC20B, WFIKKNRP, hGASP-1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
External IDs	OMIM: 610895; MGI: 2669209; HomoloGene: 35284; GeneCards: WFIKKN2; OMA:WFIKKN2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,834,650 bp[1] End 50,842,353 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 94,126,782 bp[2] End 94,136,831 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary testicle retinal pigment epithelium muscle of thigh ventricular zone right adrenal cortex left adrenal gland cerebellar hemisphere left adrenal cortex Top expressed in otolith organ utricle choroid plexus of lateral ventricle muscle of thigh choroid plexus of fourth ventricle retinal pigment epithelium Epithelium of choroid plexus thymus medial head of gastrocnemius muscle temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding receptor antagonist activity transforming growth factor beta binding Cellular component extracellular region extracellular space Biological process skeletal system development negative regulation of DNA binding roof of mouth development negative regulation of peptidase activity negative regulation of protein binding negative regulation of endopeptidase activity transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124857 278507 Ensembl ENSG00000173714 ENSMUSG00000044177 UniProt Q8TEU8 Q7TQN3 RefSeq (mRNA) NM_175575 NM_001330341 NM_181819 RefSeq (protein) NP_001317270 NP_783165 NP_861540 Location (UCSC) Chr 17: 50.83 – 50.84 Mb Chr 11: 94.13 – 94.14 Mb PubMed search [3] [4]
Wikidata
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WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.[5]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

See also

• Kazal-type serine protease inhibitor domain

References

1. GRCh38: Ensembl release 89: ENSG00000173714 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044177 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

Further reading

• Szláma G, Kondás K, Trexler M, Patthy L (December 2010). "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". The FEBS Journal. 277 (24): 5040–50. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789. S2CID 45602047.
• Hill JJ, Qiu Y, Hewick RM, Wolfman NM (June 2003). "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology. 17 (6): 1144–54. doi:10.1210/me.2002-0366. PMID 12595574.
• Kondás K, Szláma G, Trexler M, Patthy L (August 2008). "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". The Journal of Biological Chemistry. 283 (35): 23677–84. doi:10.1074/jbc.M803025200. PMC 3259755. PMID 18596030.
• Nagy A, Trexler M, Patthy L (May 2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
• Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET (May 2012). "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research. 26 (5): 1374–82. doi:10.1519/JSC.0b013e318251083f. PMID 22395277. S2CID 12311653.
• Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K (April 2010). "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology. 317 (1–2): 25–30. doi:10.1016/j.mce.2009.12.019. PMID 20026378. S2CID 25180090.
• Trexler M, Bányai L, Patthy L (January 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.