Urologic chronic pelvic pain syndrome

Urologic chronic pelvic pain syndrome (UCPPS) is ongoing bladder pain in either sex, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men and interstitial cystitis[1][2][3] or painful bladder syndrome (IC/PBS) in women.[4][5]

It was coined as an umbrella term for use in research into urologic pain syndromes in men and women.

Treatment

Multimodal therapy is the most successful treatment option in chronic pelvic pain,[6] and includes physical therapy,[7] myofascial trigger point release,[7] relaxation techniques,[7] α-blockers,[8] and phytotherapy.[9][10] The UPOINT diagnostic approach suggests that antibiotics are not recommended unless there is clear evidence of infection.[11]

Research

In 2007, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the United States National Institutes of Health (NIH), began using UCPPS as a term to refer to chronic pelvic pain syndromes (interstitial cystitis|interstitial cystitis/bladder pain syndrome (IC/BPS) in women and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men).[12]

MAPP Research Network

The NIDDK established the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network in 2008.[13]

MAPP Network scientists use a whole–body, systemic approach to the study of UCPPS, as well as investigating potential relationships between UCPPS and other chronic conditions that are sometimes seen in IC/PBS and CP/CPPS patients, such as irritable bowel syndrome, fibromyalgia, and chronic fatigue syndrome.[13]

References

1. Dimitrakov J, Joffe HV, Soldin SJ, Bolus R, Buffington CA, Nickel JC (February 2008). "Adrenocortical hormone abnormalities in men with chronic prostatitis/chronic pelvic pain syndrome". Urology. 71 (2): 261–6. doi:10.1016/j.urology.2007.09.025. PMC 2390769. PMID 18308097.
2. Masiutin MG, Yadav MK (2022). "Letter to the editor regarding the article "Adrenocortical hormone abnormalities in men with chronic prostatitis/chronic pelvic pain syndrome"". Urology. 169: 273. doi:10.1016/j.urology.2022.07.051. ISSN 0090-4295. PMID 35987379. S2CID 251657694.
3. Dimitrakoff J, Nickel JC (2022). "AUTHOR REPLY". Urology. 169: 273–274. doi:10.1016/j.urology.2022.07.049. ISSN 0090-4295. PMID 35985522. S2CID 251658492.
4. Dimitrakov J, Dimitrakova E (2009). "Urologic chronic pelvic pain syndrome--looking back and looking forward". Folia Med (Plovdiv). 51 (3): 42–4. PMID 19957562.
5. Adamian L, Urits I, Orhurhu V, Hoyt D, Driessen R, Freeman JA, Kaye AD, Kaye RJ, Garcia AJ, Cornett EM, Viswanath O (May 2020). "A Comprehensive Review of the Diagnosis, Treatment, and Management of Urologic Chronic Pelvic Pain Syndrome". Curr Pain Headache Rep. 24 (6): 27. doi:10.1007/s11916-020-00857-9. PMID 32378039. S2CID 218513050.
6. Potts JM (2005). "Therapeutic options for chronic prostatitis/chronic pelvic pain syndrome". Current Urology Reports. 6 (4): 313–7. doi:10.1007/s11934-005-0030-5. PMID 15978236. S2CID 195364765.
7. Potts J, Payne RE (May 2007). "Prostatitis: Infection, neuromuscular disorder, or pain syndrome? Proper patient classification is key". Cleve Clin J Med. 74 (Suppl 3): S63–71. doi:10.3949/ccjm.74.suppl_3.s63. PMID 17549825.
8. Yang G, Wei Q, Li H, Yang Y, Zhang S, Dong Q (2006). "The effect of alpha-adrenergic antagonists in chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis of randomized controlled trials". J. Androl. 27 (6): 847–52. doi:10.2164/jandrol.106.000661. PMID 16870951. ...treatment duration should be long enough (more than 3 months)
9. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999). "Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial". Urology. 54 (6): 960–3. doi:10.1016/S0090-4295(99)00358-1. PMID 10604689.
10. Elist J (2006). "Effects of pollen extract preparation Prostat/Poltit on lower urinary tract symptoms in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized, double-blind, placebo-controlled study". Urology. 67 (1): 60–3. doi:10.1016/j.urology.2005.07.035. PMID 16413333.
11. Sandhu J, Tu HY (2017). "Recent advances in managing chronic prostatitis/chronic pelvic pain syndrome". F1000Res. 6: 1747. doi:10.12688/f1000research.10558.1. PMC 5615772. PMID 29034074.
12. Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodríguez LV, et al. (August 2014). "The MAPP research network: a novel study of urologic chronic pelvic pain syndromes". BMC Urol. 14: 57. doi:10.1186/1471-2490-14-57. PMC 4134515. PMID 25085007.
13. "A New Look at Urological Chronic Pelvic Pain". Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain. Retrieved 8 March 2021.