URI1

URI1
Identifiers
Aliases	URI1, C19orf2, NNX3, PPP1R19, RMP, URI, URI1 prefoldin-like chaperone, prefoldin like chaperone, URI1 prefoldin like chaperone
External IDs	OMIM: 603494; MGI: 1342294; HomoloGene: 2813; GeneCards: URI1; OMA:URI1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q12 Start 29,923,644 bp[1] End 30,016,612 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 37,659,417 bp[2] End 37,722,976 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon left testis right testis C1 segment rectum Skeletal muscle tissue of rectus abdominis parotid gland left ovary ventricular zone islet of Langerhans Top expressed in tail of embryo genital tubercle Paneth cell substantia nigra transitional epithelium of urinary bladder skin of external ear spermatid hair follicle vas deferens Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity phosphatase inhibitor activity chromatin binding phosphoprotein binding protein binding protein phosphatase inhibitor activity RNA polymerase II complex binding Cellular component cytoplasm cell projection dendrite RNA polymerase II, core complex nucleus nucleoplasm mitochondrion cytosol Biological process cellular response to steroid hormone stimulus regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway regulation of transcription by RNA polymerase II negative regulation of phosphatase activity cellular response to growth factor stimulus response to virus negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of cell growth negative regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8725 19777 Ensembl ENSG00000105176 ENSMUSG00000030421 UniProt O94763 Q3TLD5 RefSeq (mRNA) NM_001252641 NM_003796 NM_134447 NM_011274 RefSeq (protein) NP_001239570 NP_003787 NP_035404 Location (UCSC) Chr 19: 29.92 – 30.02 Mb Chr 7: 37.66 – 37.72 Mb PubMed search [3] [4]
Wikidata
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Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene.[5][6][7]

Function

The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[7]

Interactions

URI1 has been shown to interact with DMAP1[8] and STAP1.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000105176 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030421 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J (Feb 1999). "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease". Genomics. 54 (3): 511–20. doi:10.1006/geno.1998.5609. PMID 9878255.
6. Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S (Dec 1998). "RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein". Mol Cell Biol. 18 (12): 7546–55. doi:10.1128/mcb.18.12.7546. PMC 109335. PMID 9819440.
7. "Entrez Gene: C19orf2 chromosome 19 open reading frame 2".
8. Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (Oct 2004). "Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner". Mol. Cell. Biol. 24 (19): 8556–66. CiteSeerX 10.1.1.605.6435. doi:10.1128/MCB.24.19.8556-8566.2004. PMC 516735. PMID 15367675.
9. Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

External links

• Human URI1 genome location and URI1 gene details page in the UCSC Genome Browser.

Further reading

• Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
• Wei W, Gu JX, Zhu CQ, Sun FY, Dorjsuren D, Lin Y, Murakami S (2003). "Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)". Cell Res. 13 (2): 111–20. doi:10.1038/sj.cr.7290155. PMID 12737519.
• Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (2004). "Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner". Mol. Cell. Biol. 24 (19): 8556–66. doi:10.1128/MCB.24.19.8556-8566.2004. PMC 516735. PMID 15367675.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.