The subicular complex comprises a set of four related structures including the prosubiculum, presubiculum, postsubiculum and parasubiculum.[1]
Name
The subiculum got its name from Karl Friedrich Burdach in his three-volume work Vom Bau und Leben des Gehirns (Vol. 2, §199). He originally named it subiculum cornu ammonis and so associated it with the rest of the hippocampal subfields.
The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking.[2] The transitions between these two modes is thought to be important for routing information out of the hippocampus.
Four component areas have been described:[3]parasubiculum (adjacent to the parahippocampal gyrus), presubiculum, postsubiculum, and prosubiculum.
Parasubiculum
The parasubiculum contains grid cells,[4] which are neurons responsive to movements in particular directions over particular distances.
The dorsal part of the presubiculum is more commonly known as the postsubiculum[5] and is of interest because it contains head direction cells, which are responsive to the facing direction of the head.[6]
Prosubiculum
Prosubiculum is a term often used in reference to monkey anatomy but rarely in rodents, referring to a region located between the CA1 region of the hippocampus and the subiculum, and distinguished by higher cell density and smaller cell sizes.[1]
Function
It is believed to play a role in some cases of human epilepsy.[7][8]
It has been suggested that the dorsal subiculum is involved in spatial relations, and the ventral subiculum regulates the hypothalamic-pituitary-adrenal axis.[11]
Clinical significance
Potential role in Alzheimer's disease
Rat studies indicate that lesioning of the subiculum decreases the spread of amyloid-beta in rat models of Alzheimer's disease. Alzheimer's disease pathology is thought to have prion-like properties. The disease tends to spread in characteristic sequence from the entorhinal cortex through the subiculum.[12]
Additional images
Basic circuit of the hippocampus
References
^ abDing, Song-Lin (2013-12-15). "Comparative anatomy of the prosubiculum, subiculum, presubiculum, postsubiculum, and parasubiculum in human, monkey, and rodent". The Journal of Comparative Neurology. 521 (18): 4145–4162. doi:10.1002/cne.23416. ISSN1096-9861. PMID23839777. S2CID39392210.
^Boccara, Charlotte N.; Sargolini, Francesca; Thoresen, Veslemøy Hult; Solstad, Trygve; Witter, Menno P.; Moser, Edvard I.; Moser, May-Britt (2010-08-01). "Grid cells in pre- and parasubiculum". Nature Neuroscience. 13 (8): 987–994. doi:10.1038/nn.2602. ISSN1546-1726. PMID20657591. S2CID7851286.
^Swanson, L. W.; Cowan, W. M. (1977-03-01). "An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat". The Journal of Comparative Neurology. 172 (1): 49–84. doi:10.1002/cne.901720104. ISSN0021-9967. PMID65364. S2CID40742028.
^Knopp A, Frahm C, Fidzinski P, Witte OW, Behr J (June 2008). "Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy". Brain. 131 (Pt 6): 1516–27. doi:10.1093/brain/awn095. PMID18504292.
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