Bayne-Jones was born on November 6, 1888, in New Orleans[1] as the son of physician. His grandfather Joseph Jones was also a physician and served in the medical department of the Confederate States Army during the American Civil War. In this way, Bayne-Jones was influenced in his future career choice.[1]
He became a teacher and also a researcher in the fields of bacteriology and immunology. Bayne-Jones received a commission of First Lieutenant in the Medical Reserve Corps, U.S. Army on August 7, 1915.