Gail M. Dack graduated in 1918 from Elgin High School and in 1922 with a B.S. from the University of Illinois Urbana-Champaign. He graduated in 1927 with a Ph.D. from the University of Chicago and in 1933 with an M.D. from the University of Chicago Medical School[2] (now named the Pritzker School of Medicine). In the University of Chicago's department of bacteriology, he was from 1925 to 1929 an instructor, from 1929 to 1937 an assistant professor, from 1937 to 1946 an associate professor, from 1946[3] to 1966 a full professor, and then a professor emeritus in retirement. From 1946 to 1966 he was also the director of the University of Chicago's Food Research Institute.[2] From 1952 to 1953 he chaired the National Research Council Committee on Foods.[4]
In a classic 1930 paper,[5] Dack and 3 colleagues published an account of food poisoning that occurred in Chicago in December 1929. Eleven people became sick with vomiting and severe diarrhea after eating, on slightly different occasions, three-layered sponge cake filled with cream. Separate, different, cake components were fed to monkeys and to human volunteers without ill effects. A thorough bacteriological examination of the cake substance yielded 19 different types of bacterial colonies — but the only type found to be of importance was a yellow hemolytic Staphylococcus. Using that Staphylococcus colony, the Chicago researchers prepared a sterile filtrate containing the bacterial enterotoxins. Injection of the filtrate into a rabbit caused death with severe diarrhea. Three human volunteers, namely the physicians William E. Cary, Edwin O. Jordan, and Dack, drank different volumes of the filtrate. Dack, who drank the largest volume, became violently ill, and the other two physicians had minor symptoms. Heat lability experiments established a heating protocol that safely destroyed the bacteria.[6][7] Lawrence K. Altman, M.D., gave a brief, vivid account of this self-experimentation.[8]
In 1917 Edwin O. Jordan, who later became Dack's mentor, published a 107-page monograph entitled Food Poisoning. After Jordan's death in 1936, Dack took responsibility for updates of the book and published his first version of Food Poisoning in 1943 with subsequent editions in 1949 and 1956.[2][9]
Dack, G. M.; Dragstedt, Lester R. (1938). "Effect of introducing oxygen into the isolated colon of a patient with chronic ulcerative colitis". American Journal of Digestive Diseases. 5 (2): 84–86. doi:10.1007/BF03010599.
Surgalla, Michael J.; Dack, G. M. (1955). "Enterotoxin Produced by Micrococci from Cases of Enteritis After Antibiotic Therapy". Journal of the American Medical Association. 158 (8): 649–650. doi:10.1001/jama.1955.02960080025006a. PMID14381232.
Bergdoll, M. S.; Sugiyama, H.; Dack, G.M. (1959). "Staphylococcal enterotoxin. I. Purification". Archives of Biochemistry and Biophysics. 85: 62–69. doi:10.1016/0003-9861(59)90447-3. PMID13799261.