Spitamenes was an ally of Bessus.[4][5] In 329 BC, Bessus stirred a revolt in the eastern satrapies, and the same year his allies began to be uncertain about supporting him.[6] Alexander went with his army to Drapsaca, outflanked Bessus and sent him fleeing. Bessus was then removed from power by Spitamenes, and Ptolemy was sent to catch him.[7][8][9][10]
While Alexander was founding the new city of Alexandria Eschate on the Jaxartes river, news came that Spitamenes had roused Sogdiana against him and was besieging the Macedonian garrison in Markanda. Too occupied at that time to personally lead an army against Spitamenes, Alexander sent an army under the command of Pharnuches which was promptly annihilated with a loss of no less than 2,000[5] infantry and 300 cavalry.[11]
The uprising now posed a direct threat to his army, and Alexander moved personally to relieve Markanda, only to learn that Spitamenes had left Sogdiana and was attacking Bactria, from where he was repulsed with great difficulty by the satrap of Bactria, Artabazos II (328 BC).
The decisive point came in December 328 BC when Spitamenes was defeated by Alexander's general Coenus at the Battle of Gabai. Spitamenes was killed by some treacherous nomadic tribes' leaders and they sent his head to Alexander, suing for peace.
^Magill, Frank N. et al. (1998), The Ancient World: Dictionary of World Biography, Volume 1, Pasadena, Chicago, London,: Fitzroy Dearborn Publishers, Salem Press, p. 1010, ISBN0-89356-313-7.
^Holt, Frank L. (1989), Alexander the Great and Bactria: the Formation of a Greek Frontier in Central Asia, Leiden, New York, Copenhagen, Cologne: E. J. Brill, pp 64–65 (see footnote #63 for a discussion on Spitamenes and Apama), ISBN90-04-08612-9.
^Mairs, Rachel (2020). The Graeco-Bactrian and Indo-Greek World. Taylor & Francis. ISBN978-1-351-61027-8. Interest in 'great men' was no longer limited to Alexander, but also to Central Asian figures, in particular the Sogdian Spitamenes, one of Alexander's most tenacious adversaries, connected to Samarkand, whose satrap he had been [...]
^Rice, E. E. (1997). Alexander the Great. History Press. p. 39. ISBN978-0-7524-6838-9. Alexander crossed the Tanais, again with hide rafts, in pursuit of the Scythians but turned back at the news of successful actions by Spitamenes, a Sogdian nobleman and former ally of Bessus, who had attacked the Macedonian garrison at [...]
^Debra Skelton, Pamela Dell (2005). Empire of Alexander the Great. Chelsea House. p. 39. ISBN978-1-60413-162-8. Bessus's allies were no longer certain they wanted to back him. In June of 329 B.C. about a year after Alexander began chasing Bessus, the Sogdian leader, Spitamenes, arrested his former ally.
^Walbank, Frank W. "Alexander the Great". Britannica. Archived from the original on 13 September 2021. Retrieved 11 September 2021. Crossing the Oxus, he sent his general Ptolemy in pursuit of Bessus, who had meanwhile been overthrown by the Sogdian Spitamenes.