The Southern Indiana Screaming Eagles women's basketball team represents the University of Southern Indiana in Evansville, Indiana, United States. The Screaming Eagles currently compete in the NCAADivision IOhio Valley Conference, having started a transition from Division II on July 1, 2022. Under NCAA rules for reclassifying programs, the Screaming Eagles will not be eligible to compete in the NCAA tournament until the 2026–27 season. The Screaming Eagles will be eligible to play in the WNIT, which unlike its men's counterpart is not operated by the NCAA.
During their time in NCAA Division II, the Screaming Eagles were selected to play in the NCAA Division II women's basketball tournament twelve times. They were selected for the 2020 tournament, but it was not held due to the cancellation of the tournament with the COVID-19 pandemic. They had a combined record of 8–11.