Sohini Ramachandran

Sohini Ramachandran
Education	Stanford University
Alma mater	Stanford University
Scientific career
Thesis	The signature of historical migrations on human population genetic data (2007)
Doctoral advisor	Marcus Feldman
Website	https://brown.edu/Research/Ramachandran_Lab/

Sohini Ramachandran is professor at Brown University known for her work in evolutionary biology and population genetics.

Early life and education

Ramachandran's parents were both professors.[1] In the summer before her senior year of high school, Ramachandran completed a research project in plant genomics under the guidance of Marcus Feldman, which won her the fourth place prize in the 1998 Westinghouse Science Talent Search,[2] where when she was the youngest finalist in the group.[3] Ramachandran earned a B.S. from Stanford University in 2002. She went on to complete a Ph.D. at Stanford University in the Department of Biological Sciences, advised by Marcus Feldman. Her dissertation research was dissertation was titled "The signature of historical migrations on human population genetic data."[4] Following her PhD, she was in the Harvard Society of Fellows as a postdoctoral researcher with John Wakeley in Harvard University's Department of Organismic and Evolutionary Biology.[5] She moved to Brown University in 2010 and was promoted to professor in 2021.[5] In 2019, she was a fellow at the Swedish Collegium for Advanced Study.[6]

Research

Ramachandran's research group uses statistical and mathematical modeling techniques to study evolutionary biology and population genetics. Her early research examined the genetic relationships originating within people from Africa,[7][8] where she showed that diversity decreases as distance from Africa increases.[9] She has also investigated the use of genetic tools to track infectious diseases[10][11] and shown that while more outbreaks are occurring, fewer people are getting infected.[12] She has also shown a lack of genetic evidence for selection for language at the FOXP2 site.[13]

Selected publications

• Li, Jun Z.; Absher, Devin M.; Tang, Hua; Southwick, Audrey M.; Casto, Amanda M.; Ramachandran, Sohini; Cann, Howard M.; Barsh, Gregory S.; Feldman, Marcus; Cavalli-Sforza, Luigi L.; Myers, Richard M. (2008-02-22). "Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation". Science. 319 (5866): 1100–1104. Bibcode:2008Sci...319.1100L. doi:10.1126/science.1153717. ISSN 0036-8075. PMID 18292342. S2CID 53541133.
• Ramachandran, Sohini; Deshpande, Omkar; Roseman, Charles C.; Rosenberg, Noah A.; Feldman, Marcus W.; Cavalli-Sforza, L. Luca (2005). "Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa". Proceedings of the National Academy of Sciences. 102 (44): 15942–15947. Bibcode:2005PNAS..10215942R. doi:10.1073/pnas.0507611102. ISSN 0027-8424. PMC 1276087. PMID 16243969.
• Wang, Sijia; Lewis, Cecil M. Jr.; Jakobsson, Mattias; Ramachandran, Sohini; Ray, Nicolas; Bedoya, Gabriel; Rojas, Winston; Parra, Maria V.; Molina, Julio A.; Gallo, Carla; Mazzotti, Guido (2007-11-23). "Genetic Variation and Population Structure in Native Americans". PLOS Genetics. 3 (11): e185. doi:10.1371/journal.pgen.0030185. ISSN 1553-7404. PMC 2082466. PMID 18039031.
• Ramachandran, Sohini; Rosenberg, Noah A.; Zhivotovsky, Lev A.; Feldman, Marcus W. (2004). "Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites". Human Genomics. 1 (2): 87–97. doi:10.1186/1479-7364-1-2-87. ISSN 1479-7364. PMC 3525066. PMID 15601537.

Honors and awards

In 2012, Ramachandran received a Sloan Research Fellowship[14] and was named a Pew Scholar.[15] From Brown University she has received the Henry Merritt Wriston Fellowship (2016)[16] and the Philip J. Bray Award for excellence in teaching.[17] In 2019, she received a Presidential Early Career Award in Science and Engineering.[18][19]

References

1. Chen, Ling-Ling; Claw, Katrina G.; Ramachandran, Sohini (2016). "A two-fold challenge: the experience of women of color in genomics". Genome Biology. 17 (1): 210. doi:10.1186/s13059-016-1075-0. ISSN 1474-760X. PMC 5059990. PMID 27729075.
2. Chiu, Yvonne (1998-03-09). "Fair Oaks teen gets national honor". The Sacramento Bee. p. 2. Retrieved 2022-04-17.
3. Alcala, Carlos (1998-01-28). "Fair Oaks teen, like sister, is on academic fast track". The Sacramento Bee. pp. [1], [2]. Retrieved 2022-04-17.
4. Ramachandran, Sohini (2007). The signature of historical migrations on human population genetic data (Thesis). OCLC 269371999.
5. "Sohini Ramachandran Lab: people". brown.edu. Retrieved 2022-04-17.
6. "SCAS: Sohini Ramachandran". www.swedishcollegium.se. Retrieved 2022-01-22.
7. Ramachandran, Sohini; Deshpande, Omkar; Roseman, Charles C.; Rosenberg, Noah A.; Feldman, Marcus W.; Cavalli-Sforza, L. Luca (2005). "Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa". Proceedings of the National Academy of Sciences. 102 (44): 15942–15947. Bibcode:2005PNAS..10215942R. doi:10.1073/pnas.0507611102. ISSN 0027-8424. PMC 1276087. PMID 16243969.
8. Henn, Brenna M.; Gignoux, Christopher R.; Jobin, Matthew; Granka, Julie M.; Macpherson, J. M.; Kidd, Jeffrey M.; Rodríguez-Botigué, Laura; Ramachandran, Sohini; Hon, Lawrence; Brisbin, Abra; Lin, Alice A. (2011-03-29). "Hunter-gatherer genomic diversity suggests a southern African origin for modern humans". Proceedings of the National Academy of Sciences. 108 (13): 5154–5162. doi:10.1073/pnas.1017511108. ISSN 0027-8424. PMC 3069156. PMID 21383195.
9. Scudellari, Megan (June 2012). "Sohini Ramachandran: Population Tracker". The Scientist Magazine®. Retrieved 2022-04-17.
10. Smith, Katherine F.; Goldberg, Michael; Rosenthal, Samantha; Carlson, Lynn; Chen, Jane; Chen, Cici; Ramachandran, Sohini (2014-12-06). "Global rise in human infectious disease outbreaks". Journal of the Royal Society Interface. 11 (101): 20140950. doi:10.1098/rsif.2014.0950. PMC 4223919. PMID 25401184.
11. Nakka, Priyanka; Raphael, Benjamin J; Ramachandran, Sohini (2016-10-01). "Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases". Genetics. 204 (2): 783–798. doi:10.1534/genetics.116.188391. ISSN 1943-2631. PMC 5068862. PMID 27489002.
12. Berman, Jessica (October 29, 2014). "Global Infection Outbreaks Rise over Past 30 Years". Voice of America News / FIND; Washington.
13. Atkinson, Elizabeth Grace; Audesse, Amanda Jane; Palacios, Julia Adela; Bobo, Dean Michael; Webb, Ashley Elizabeth; Ramachandran, Sohini; Henn, Brenna Mariah (2018-09-06). "No Evidence for Recent Selection at FOXP2 among Diverse Human Populations". Cell. 174 (6): 1424–1435.e15. doi:10.1016/j.cell.2018.06.048. ISSN 0092-8674. PMC 6128738. PMID 30078708.
14. "Sohini Ramachandran, Ph.D." pew.org. August 23, 2012. Retrieved 2022-01-13.
15. "Eight Women Win Pew Scholarships in the Biomedical Sciences". Women in Academia Report; Bartonsville. July 3, 2012.
16. "Sohini Ramchandran awarded Wriston Fellowship". CCMB | Brown University. Retrieved 2022-04-17.
17. Gimenes, Livia (2021-07-03). "Sohini Ramachandran Receives The Philip J. Bray Award For Excellence In Teaching In The Physical Sciences". awards.cs.brown.edu. Retrieved 2022-04-17.
18. "Two Brown researchers earn top White House award for early-career scientists". Brown University. Retrieved 2022-01-13.
19. Abbey Bigler and Talylor Walter (26 February 2020). "PECASE Honoree Sohini Ramachandran Studies the Genetic Foundations of Traits in Diverse Populations". NIGMS Biomedical Beat Blog. Retrieved 2022-04-17.

External links

• Research group website

External links

• Sohini Ramachandran publications indexed by Google Scholar