Charlotte Frederica Caroline Osborn (c. 1836–1908), who married Gen, Sir Edward Harris Greathed, son of Edward Greathed and Mary Elizabeth Glyn, in 1869.[3]
Laura Elizabeth Osborn (1838–1858), who died unmarried at age 20.[3]
Henry John Robert Osborn (1839–1889), a lieutenant in the 1st Life Guards; he married Emily St Quintin, daughter of Thomas St Quintin, in 1866.
Francis Mark Seymour Osborn (1841–1908), a captain in the Royal Navy who died unmarried.[3]
Mark Charles Davers Osborn (1845–1928), a lieutenant in the Royal Navy; he married Mary Courtenay Platt, daughter of William Platt, in 1872. After her death in 1884, he married Mary Anne Bell Fulton, daughter of W. B. Fulton, in 1885. After her death, he married Clare Harriet (née Knight), daughter of John Knight and widow of the Rev. Henry Gordon Cranmer, in 1904.[3]
Mary Louisa Osborn (1847–1920), who died unmarried.[3]
Arthur Edward Danvers Osborn (1849–1888), a Reverend who was the vicar at Haynes, Bedfordshire; he died unmarried.[3]
Emily Fanny Dorothy Osborn (1851–1925), who married her cousin, Hon. Mark Henry Horace McDonnell, son of Mark McDonnell, 5th Earl of Antrim, in 1892.[3]
Harriet Jane Osborn (1852–1882), who married Francis Basil Pulteney, son of Rev. Richard Thomas Pulteney and Emma Dalison, in 1881.[3]
Edith Caroline Agnes Osborn (1854–1914), who died unmarried.[3]
Sir George died on 11 January 1892 at age 78 at Biggleswade, Bedfordshire, England. As his eldest son had died in a collision in the English Channel between the RMT paddle steamers Princesse Henriette and Comtesse de Flandre in 1889, he was succeeded in the baronetcy by his grandson, Algernon Kerr Butler Osborn.[3]