As the winner of the preliminary rounds on Saint Pierre and Miquelon, A.S. Saint Pierraise would have gained entry to the third round draw of the Pays de la Loire region.[9] However, on 8 September 2020, the overseas territory banned travel to mainland France due to the ongoing COVID-19 situation. The side had been due to depart on 12 September, travelling via Montreal and Paris.[10] The club was scheduled to take on La Roche VF eight days later.[11]
In May 2021 it was announced that A.S. Saint Pierraise would not receive an automatic qualification to the third round of the 2021–22 Coupe de France despite losing the opportunity the previous year because of the COVID-19 pandemic. The first and second round local qualification matches were played between 7 July and 24 July 2021 with the winner participating in the Pays de la Loire region third round in September 2021.[12]A.S. Miquelonnaise received a bye to the second round match as the reigning champions of the Ligue SPM from the 2020 season.[13]A.S. Saint Pierraise took on USSA Vertou in France, ultimately losing the match 0–8.[14]
