SLC23A1

SLC23A1
Identifiers
Aliases	SLC23A1, SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1
External IDs	OMIM: 603790; MGI: 1341903; HomoloGene: 40769; GeneCards: SLC23A1; OMA:SLC23A1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 139,367,196 bp[1] End 139,384,553 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B2|18 19.17 cM Start 35,747,657 bp[2] End 35,760,297 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right uterine tube jejunal mucosa right lobe of liver olfactory zone of nasal mucosa duodenum mucosa of transverse colon human kidney mucosa of paranasal sinus bronchial epithelial cell Top expressed in proximal tubule right kidney human kidney yolk sac left lobe of liver lacrimal gland proximal straight tubule jejunum uterus seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function nucleobase transmembrane transporter activity transporter activity dehydroascorbic acid transmembrane transporter activity sodium ion transmembrane transporter activity protein binding L-ascorbate:sodium symporter activity symporter activity L-ascorbic acid transmembrane transporter activity transmembrane transporter activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane basal plasma membrane apical plasma membrane intracellular organelle extracellular exosome brush border Biological process lung development sodium ion transport ion transport L-ascorbic acid transmembrane transport brain development nucleobase transport transmembrane transport nucleobase-containing compound metabolic process response to toxic substance dehydroascorbic acid transport L-ascorbic acid metabolic process sodium ion transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9963 20522 Ensembl ENSG00000170482 ENSMUSG00000024354 UniProt Q9UHI7 Q9Z2J0 RefSeq (mRNA) NM_005847 NM_152685 NM_011397 RefSeq (protein) NP_005838 NP_689898 NP_035527 Location (UCSC) Chr 5: 139.37 – 139.38 Mb Chr 18: 35.75 – 35.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[5][6][7]

Function

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000170482 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024354 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
6. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.
7. "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Further reading

• Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616. S2CID 22478598.
• Hogue DL, Ling V (July 1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
• Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (September 1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
• Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (November 1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1461 (1): 1–9. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.
• Daruwala R, Song J, Koh WS, Rumsey SC, Levine M (November 1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521. S2CID 37936975.
• Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (January 2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.
• Erichsen HC, Eck P, Levine M, Chanock S (October 2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition. 131 (10): 2623–7. doi:10.1093/jn/131.10.2623. PMID 11584081.
• Hediger MA (May 2002). "New view at C". Nature Medicine. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580. S2CID 787845.
• Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC (March 2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.
• Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L (December 2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology. 283 (6): C1696-704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
• Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (August 2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
• Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ (February 2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery". American Journal of Epidemiology. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.
• Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ (March 2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.