SESN1

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103; MGI: 2155278; HomoloGene: 8697; GeneCards: SESN1; OMA:SESN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 108,984,309 bp[1] End 109,094,846 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.77 cM Start 41,685,931 bp[2] End 41,784,420 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis muscle of thigh thoracic diaphragm glutes gastrocnemius muscle muscle of arm biceps brachii Skeletal muscle tissue of biceps brachii triceps brachii muscle right ovary Top expressed in myocardium of ventricle intercostal muscle conjunctival fornix ciliary body cerebellar vermis interventricular septum iris lobe of cerebellum retinal pigment epithelium vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity peroxiredoxin activity protein binding leucine binding oxidoreductase activity, acting on peroxide as acceptor Cellular component cytosol cytoplasm GATOR2 complex nucleus fibrillar center TORC2 complex Biological process regulation of response to reactive oxygen species reactive oxygen species metabolic process cellular oxidant detoxification negative regulation of TORC1 signaling cellular response to amino acid starvation cellular response to glucose starvation positive regulation of macroautophagy cellular response to amino acid stimulus cellular response to leucine cellular response to leucine starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27244 140742 Ensembl ENSG00000080546 ENSMUSG00000038332 UniProt Q9Y6P5 P58006 RefSeq (mRNA) NM_014454 NM_001199933 NM_001199934 NM_001013370 NM_001162908 RefSeq (protein) NP_001186862 NP_001186863 NP_055269 NP_001013388 NP_001156380 Location (UCSC) Chr 6: 108.98 – 109.09 Mb Chr 10: 41.69 – 41.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6][7]

See also

• SESN2

References

1. GRCh38: Ensembl release 89: ENSG00000080546 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038332 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sestrin 1".
6. Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
7. Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Further reading

• Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. Bibcode:2004Sci...304..596B. doi:10.1126/science.1095569. PMID 15105503. S2CID 27871118.
• Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115. S2CID 22257894.
• Jing, Y., Zuo, Y., Sun, L., Yu, Z. R., Ma, S., Hu, H., ... & Wang, S. (2023). "SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing". Cell Proliferation, e13455. PMID 37199024 PMC 10212707 doi:10.1111/cpr.13455