RRN3

RRN3
Identifiers
Aliases	RRN3, A-270G1.2, TIFIA, RRN3 homolog, RNA polymerase I transcription factor
External IDs	OMIM: 605121; MGI: 1925255; HomoloGene: 39531; GeneCards: RRN3; OMA:RRN3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.11 Start 15,060,033 bp[1] End 15,094,311 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,598,572 bp[2] End 13,632,703 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence gastrocnemius muscle ventricular zone endometrium islet of Langerhans rectum subcutaneous adipose tissue ovary muscle of thigh Top expressed in cumulus cell neural tube cardiac muscle tissue of left ventricle epiblast spermatocyte morula morula ventricular zone muscle of thigh ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase binding RNA polymerase I core promoter sequence-specific DNA binding RNA polymerase I core binding RNA polymerase I general transcription initiation factor activity Cellular component nucleolus nucleoplasm nucleus Biological process in utero embryonic development nucleolus organization positive regulation of neuron projection development regulation of transcription, DNA-templated cell population proliferation negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator DNA-templated transcription, initiation regulation of DNA-templated transcription, initiation positive regulation of transcription, DNA-templated cytoplasm organization transcription, DNA-templated homeostasis of number of cells transcription initiation from RNA polymerase I promoter ribosome biogenesis regulation of transcription by RNA polymerase I RNA polymerase I preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54700 106298 Ensembl ENSG00000085721 ENSG00000278494 ENSMUSG00000022682 UniProt Q9NYV6 B2RS91 RefSeq (mRNA) NM_001301064 NM_018427 NM_001039521 RefSeq (protein) NP_001287993 NP_060897 NP_001034610 Location (UCSC) Chr 16: 15.06 – 15.09 Mb Chr 16: 13.6 – 13.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.[5][6][7]

Interactions

RRN3 has been shown to interact with TAF1B.[6]

References

1. ENSG00000278494 GRCh38: Ensembl release 89: ENSG00000085721, ENSG00000278494 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022682 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. Bibcode:2000PNAS...97.4724M. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.
6. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
7. "Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I (2000). "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p". EMBO Rep. 1 (2): 171–5. doi:10.1093/embo-reports/kvd032. PMC 1084264. PMID 11265758.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
• Zhao J, Yuan X, Frödin M, Grummt I (2003). "ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth". Mol. Cell. 11 (2): 405–13. doi:10.1016/S1097-2765(03)00036-4. PMID 12620228.
• Mayer C, Zhao J, Yuan X, Grummt I (2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
• Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I (2004). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034. S2CID 6633625.