Phenethyl isothiocyanate
Names
Preferred IUPAC name
(2-Isothiocyanatoethyl)benzene
Other names
Phenylethyl isothiocyanate; Phenethyl mustard oil
Identifiers
Abbreviations
PEITC
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
100.017.142
UNII
InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
Y Key: IZJDOKYDEWTZSO-UHFFFAOYSA-N
Y InChI=1/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
Key: IZJDOKYDEWTZSO-UHFFFAOYAB
Properties
C 9 H 9 N S
Molar mass
163.24 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Phenethyl isothiocyanate (PEITC ) is a naturally occurring isothiocyanate whose precursor, gluconasturtiin is found in some cruciferous vegetables ,[ 1] especially watercress .
PEITC has been studied for its potential for chemoprevention of cancers,[ 2] [ 3] such as prostate cancer.[ 4]
In terms of biosynthesis , PEITC is produced from gluconasturtiin by the action of the enzyme myrosinase .
References
^ "Dictionary of Cancer Terms: PEITC" . National Cancer Institute .
^ Cheung, KL; Kong, AN (2010). "Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention" . The AAPS Journal . 12 (1): 87– 97. doi :10.1208/s12248-009-9162-8 . PMC 2811646 . PMID 20013083 .
^ Kwon, Ki Han; Xu, Changjiang; Keum, Young-Sam; Khor, Tin Oo; Kim, Jung-Hwan; Huang, Mou-Tuan; Reddy, Bandaru S.; Li, Wenge; Kong, Ah-Ng Tony (2007). "Natural dietary phytochemicals: a promising future for cancer prevention and treatment of earlier lesion". Cancer: Disease Progression and Chemoprevention : 109– 126.
^ Wang, LG; Chiao, JW (2010). "Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review)" . International Journal of Oncology . 37 (3): 533– 9. doi :10.3892/ijo_00000702 . PMID 20664922 .