Peyton Jacob III

Peyton Jacob III
Other names	Peyton Jacob the Third; Peyton Jacob the 3rd
Alma mater	University of California, Davis (B.S.); Purdue University (Ph.D.)
Occupation(s)	Chemist; Pharmacologist
Years active	1972–present
Organization	University of California, San Francisco
Website	https://tobaccoresearchcenter.ucsf.edu/peyton-jacob-iii-phd https://cancer.ucsf.edu/people/jacob.peyton

Peyton Jacob III is an American chemist and pharmacologist who has studied nicotine, methamphetamine, hallucinogens, entactogens, and other psychoactive drugs.[1][2] He is a researcher at the University of California, San Francisco (UCSF).[1][2] Jacob extensively collaborated with and was close friends with Alexander Shulgin.[3][2] Among many other contributions, they developed the Shulgin Rating Scale together[4] and methylone was first synthesized and described by the pair in the mid-1990s.[5][6][7]

Selected publications

• Braun U, Braun G, Jacob P, Nichols DE, Shulgin AT (1978). "Mescaline analogs: substitutions at the 4-position" (PDF). NIDA Res Monogr (22): 27–37. PMID 101882.
• Shulgin AT, Shulgin LA, Jacob P (May 1986). "A protocol for the evaluation of new psychoactive drugs in man". Methods Find Exp Clin Pharmacol. 8 (5): 313–320. PMID 3724306.
• Nichols DE, Hoffman AJ, Oberlender RA, Jacob P, Shulgin AT (October 1986). "Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class" (PDF). J Med Chem. 29 (10): 2009–2015. doi:10.1021/jm00160a035. PMID 3761319.
• Benowitz NL, Porchet H, Sheiner L, Jacob P (July 1988). "Nicotine absorption and cardiovascular effects with smokeless tobacco use: comparison with cigarettes and nicotine gum" (PDF). Clin Pharmacol Ther. 44 (1): 23–8. doi:10.1038/clpt.1988.107. PMID 3391001.
• Jacob P, Shulgin AT (1994). "Structure-activity relationships of the classic hallucinogens and their analogs" (PDF). NIDA Res Monogr. 146: 74–91. PMID 8742795.
• Mendelson J, Jones RT, Upton R, Jacob P (May 1995). "Methamphetamine and ethanol interactions in humans". Clin Pharmacol Ther. 57 (5): 559–568. doi:10.1016/0009-9236(95)90041-1. PMID 7768079.
• Pérez-Stable EJ, Herrera B, Jacob P, Benowitz NL (July 1998). "Nicotine metabolism and intake in black and white smokers" (PDF). JAMA. 280 (2): 152–156. doi:10.1001/jama.280.2.152. PMID 9669788.
• Cozzi NV, Sievert MK, Shulgin AT, Jacob P, Ruoho AE (September 1999). "Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines". Eur J Pharmacol. 381 (1): 63–69. doi:10.1016/s0014-2999(99)00538-5. PMID 10528135.
• Mendelson J, Uemura N, Harris D, Nath RP, Fernandez E, Jacob P, Everhart ET, Jones RT (October 2006). "Human pharmacology of the methamphetamine stereoisomers" (PDF). Clin Pharmacol Ther. 80 (4): 403–420. doi:10.1016/j.clpt.2006.06.013. PMID 17015058.
• Benowitz NL, Hukkanen J, Jacob P (2009). "Nicotine chemistry, metabolism, kinetics and biomarkers" (PDF). Handb Exp Pharmacol (192): 29–60. doi:10.1007/978-3-540-69248-5_2. PMC 2953858. PMID 19184645.
• Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, Jacob P, Benowitz N (March 2014). "Levels of selected carcinogens and toxicants in vapour from electronic cigarettes" (PDF). Tob Control. 23 (2): 133–139. doi:10.1136/tobaccocontrol-2012-050859. PMC 4154473. PMID 23467656.

References

1. Norris, Jeffrey (17 April 2013). "Smoking from Hookah Not a Harmless Alternative to Cigarettes". Smoking from Hookah Not a Harmless Alternative to Cigarettes. Retrieved 30 January 2025.
2. Hamilton Morris (28 November 2023). "POD 92: Understanding and Improving MDMA with Dr. Matthew Baggott". The Hamilton Morris Podcast (Podcast). Patreon. Retrieved 30 November 2024.
3. Baggot MJ (2018). "Seed crystal: on the contributions of Alexander Shulgin to the science of consciousness". The Commemorative Edition of Pihkal and Tihkal. Berkeley: Transform Press. pp. 474–482. ISBN 9780963009661. OCLC 1176317484.
4. Shulgin AT, Shulgin LA, Jacob P (May 1986). "A protocol for the evaluation of new psychoactive drugs in man". Methods Find Exp Clin Pharmacol. 8 (5): 313–320. PMID 3724306.
5. James W. Jesso (1 June 2023). "Entactogens, MDMA, and Bringing New Love Drugs To Market (with Matthew Baggott)". Adventures Through The Mind (Podcast). Retrieved 27 January 2025.
6. Trott, D.M. (2022). The Drug Users Bible [Extended Edition]. MxZero Publishing. p. 256. ISBN 978-0-9955936-9-5. Retrieved 30 January 2025.
7. WO 9639133, Jacob III P, Shulgin AT, "Novel N-Substituted-2-Amino-3',4'-Methylene-dioxypropiophenones", published 1996-12-12, assigned to Neurobiological Technologies Inc.