en Nitroxinil

Nitroxinil
	Structure of nitroxinil
Clinical data
Trade names	Fluconix, Dovenix, Trodax
Other names	Nitroxynil
Routes of; administration	Subcutaneous in the form of an N-Ethylglucamine salt solution
ATCvet code	QP52AG08 (WHO) ;
Identifiers
	IUPAC name 4-Hydroxy-3-iodo-5-nitrobenzonitrile;
CAS Number	1689-89-0;
PubChem CID	15532;
UNII	9L0EXQ7125;
CompTox Dashboard (EPA)	DTXSID9075117 ;
ECHA InfoCard	100.015.350
Chemical and physical data
Formula	C7H3IN2O3
Molar mass	290.016 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	136–139 °C (277–282 °F)
	SMILES C1=C(C=C(C(=C1[N+](=O)[O-])O)I)C#N;
	InChI InChI=1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H;

Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle. The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract.^[1] Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.^{[citation needed]}

Nitroxinil was invented by May & Baker^[2] in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to Nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group.

Nitroxynil is almost insoluble in water. It is usually injected subcutaneously into the animals in the form of the water-soluble ethylglucamine salt.^[1] It must not be administered to animals that produce milk for human consumption.^[3]

References

^ ^a ^b "NITROXINIL = NITROXYNIL for veterinary use in CATTLE, SHEEP and GOATS against flukes and roundworms". Retrieved 4 April 2018.
^ GB 1104885, May & Baker, "Method for the Treatment of Helminth Infestations", published 18 Dec 1964, issued 6 Mar 1968
^ "Committee for Veterinary Medicinal Products, Nitroxinil, Summary Report" (PDF). The European Agency for the Evaluation of Medical Products. June 1998. p. 5. Retrieved 4 April 2018.

External links

Chemicalland21.com

[parasitipedia-1] "NITROXINIL = NITROXYNIL for veterinary use in CATTLE, SHEEP and GOATS against flukes and roundworms". Retrieved 4 April 2018.

[2] GB 1104885, May & Baker, "Method for the Treatment of Helminth Infestations", published 18 Dec 1964, issued 6 Mar 1968

[3] "Committee for Veterinary Medicinal Products, Nitroxinil, Summary Report" (PDF). The European Agency for the Evaluation of Medical Products. June 1998. p. 5. Retrieved 4 April 2018.

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Nitroxinil

References

External links

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