Vasdev began his independent faculty career at CAMH/University of Toronto in 2004. From 2011–2017 he served as the director of radiochemistry and an associate centre director at the Massachusetts General Hospital and served as an associate professor in the department of radiology at Harvard Medical School from 2012–2022. He was recruited back to CAMH and the University of Toronto in November 2017.
Research award of John R. Evans Leaders Fund 2019–2024 (specialty: Radiochemistry) from Canada Foundation for Innovation. This funding supports his proposal: "Automated apparatus for PET radiopharmaceuticals to image the living human brain"[citation needed]
Research award of Endowed Azrieli Chair in Brain and Behaviour 2018–2023 (Specialty: Neuroimaging) from University of Toronto.[12]
Research Award of Tier 1 Canada Research Chair in Radiochemistry and Nuclear Medicine 2017–2024 (specialty: Radiochemistry and Nuclear Medicine) from Canadian Institutes for Health Research (CIHR).[1]
Leaders Opportunity Fund (Research Infrastructure) 2009–2014 (specialty: Radiochemistry) from Canadian Foundation for Innovation.[13]
Current methods to radiofluorinate non-activated aromatic rings are generally limited to esoteric electrophilic [18F]F2 reactions, transition-metal mediated, or iodonium salt based methods. The Vasdev Lab has a long-established history of labeling non-activated aromatics and recently discovered a simple synthetic strategy for incorporating [18F]fluoride into non-activated aromatic molecules using spirocyclic iodoium ylide based precursors. Based on their paper in Nature Communications, a patent has been licensed by the pharmaceutical industry to employ this method for the synthesis of radiopharmaceuticals in humans. Hence, the iodonium ylide technology for fluorination represents a major advance for PET imaging.[14]
11C-fixation strategies
There is a need for new methods of 11C radiosynthesis because current methods are largely limited to methylation. The Vasdev lab has co-developed new techniques of 11CO2 fixation that are suitable for human use with diverse precursors synthesized by labeling at the carbonyl group (rather than the common methyl group). This methodology can label 11C-carbamates for imaging the enzyme FAAH ([11C]CURB) or 11C-oxazolidinones for imaging MAO-B (11C-SL25.1188), both of which they have translated for human use. They have also synthesized 11C-ureas and a 11C-carboxylic acid (11C-Bexarotene).[15]
New PET radiopharmaceuticals for Alzheimer's disease and brain injuries
Vasdev has introduced new radiochemical methods and radiopharmaceuticals for imaging the living human brain.[16] The Vasdev Lab is exploring new ways to image neuroinflammation and tau protein.[17] He is the co-inventor of the method patent for the first and only FDA-approved tau-PET radiopharmaceutical Tauvid that has been employed worldwide to image patients with Alzheimer's disease (AD) and related dementias, as well as patients with symptomatic traumatic brain injuries, including professional athletes and military veterans. The Vasdev Lab is partnering with Concussion Legacy Foundation Canada and the Canadian Military to work on the Project Enlist to study whether some military training exercises could be negatively impacting long-term brain health.[3][18][4] “We are getting very close to advancing new radio tracers in humans to image the tau that is more prevalent in C.T.E.”.[6]
Selected publications
Vasdev has over 10 families of patents and has published more than 150 peer-reviewed papers including:
Clouston, Sean A. P.; Hall, Charles B.; Kritikos, Minos; Bennett, David A.; DeKosky, Steven; Edwards, Jerri; Finch, Caleb; Kreisl, William C.; Mielke, Michelle; Peskind, Elaine R.; Raskind, Murray; Richards, Marcus; Sloan, Richard P.; Spiro, Avron; Vasdev, Neil; Brackbill, Robert; Farfel, Mark; Horton, Megan; Lowe, Sandra; Lucchini, Roberto G.; Prezant, David; Reibman, Joan; Rosen, Rebecca; Seil, Kacie; Zeig-Owens, Rachel; Deri, Yael; Diminich, Erica D.; Fausto, Bernadette A.; Gandy, Sam; Sano, Mary; Bromet, Evelyn J.; Luft, Benjamin J. (23 February 2022). "Cognitive impairment and World Trade Centre-related exposures". Nature Reviews Neurology. 18 (2): 103–116. doi:10.1038/s41582-021-00576-8. PMC8938977. PMID34795448.
Liang, Steven H.; Chen, Jinshan Michael; Normandin, Marc D.; Chang, Jeanne S.; Chang, George C.; Taylor, Christine K.; Trapa, Patrick; Plummer, Mark S.; Para, Kimberly S.; Conn, Edward L.; Lopresti-Morrow, Lori; Lanyon, Lorraine F.; Cook, James M.; Richter, Karl E. G.; Nolan, Charlie E.; Schachter, Joel B.; Janat, Fouad; Che, Ye; Shanmugasundaram, Veerabahu; Lefker, Bruce A.; Enerson, Bradley E.; Livni, Elijahu; Wang, Lu; Guehl, Nicolas J.; Patnaik, Debasis; Wagner, Florence F.; Perlis, Roy; Holson, Edward B.; Haggarty, Stephen J.; El Fakhri, Georges; Kurumbail, Ravi G.; Vasdev, Neil (8 August 2016). "Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging". Angewandte Chemie International Edition. 55 (33): 9601–9605. doi:10.1002/anie.201603797. PMC4983481. PMID27355874.
