Michaela "Mikmik" Dimaano is a bright, wise cracking 9-year-old girl living happily with her mother Ella and her adoptive grandmother Ester in a quiet province. Everything changes when Ella is diagnosed with late onset leukemia, the same time Mikmik discovers her true relations to Divina Salvador, a wealthy businesswoman. In order to pay for her mother's medication, Mikmik, with the help of Ester, visits Divina but is rejected, as Ella is blamed for her step-brother Eric's death. Ella then dies, and Mikmik is taken by Ruth, her late mother's best friend, to live with the Salvadors.
The Salvador family consists of the matriarch, Divina – the wife of the late Gabriel Salvador and head of El Salvador Builders, Katrina – a business executive and wife of Divina's late son Eric, and Katrina's daughters: the harsh and envious Amber, and the misguided but kind hearted Britney. Mikmik immediately finds refuge and comfort in Benjie and Ruth's son Joseph, but has to face the spite and cruelties of her cold step-grandmother Divina, her wicked step-aunt Katrina, and her older step-cousin Amber. Divina and Katrina's hatred stem from the fact that Mikmik is the only rightful heir to the Salvador wealth: Ella is the legitimate child of Gabriel as his marriage with her mother Letty was not annulled, making Divina a mistress, and Eric was Divina's adoptive son, due to the fact she cannot bear children.
When a mysterious man from the past named Michael Villaluna resurfaces and creates a paternal connection with Mikmik, things escalate to greater heights. As family feuds worsen, no lies will remain undiscovered, no secrets will remain unrevealed, and eventually Mikmik will get the happiness and the complete family that she truly deserves.