Shifman is known for a number of basic contributions to quantum chromodynamics, the theory of strong interactions, and to understanding of supersymmetric gauge dynamics. The most important results due to M. Shifman are diverse and include (i) the discovery of the penguin mechanism in the flavor-changing weak decays (1974);[1] (ii) introduction of the gluon condensate and development of the SVZ sum rules relating properties of the low-lying hadronic states to the vacuum condensates (1979);[2] (iii) introduction of the invisible (aka KSVZ) axion (1980)[3] (iv) first exact results in supersymmetric Yang–Mills theories (NSVZ beta function, gluino condensate,1983–1988);[4] (v) heavy quark theory based on the operator product expansion (1985–1995);[5] (vi) critical domain walls (D-brane analogs) in super-Yang-Mills (1996);[6] (vii) non-perturbative (exact) planar equivalence between super-Yang–Mills and orientifold non-supersymmetric theories (2003);[7] (viii) non-Abelian flux tubes and confined monopoles (2004 till present).[8] His paper with A. Vainshtein and Zakharov on the SVZ sum rules[2] is among the all-time top cited papers in high-energy physics.
Mikhail A. Shifman (2001). "Foreword and Notes from the Editor". In Mikhail A. Shifman (ed.). At The Frontier of Particle Physics: Handbook of QCD (On the occasion of the 75th birthday of Professor Boris Ioffe, in 3 volumes). Singapore: World Scientific. doi:10.1142/9789812810458_fmatter. ISBN981-02-4445-2.
M. Shifman, ed. (2007). Felix Berezin, The Life and Death of the Mastermind of Supermathematics. Singapore: World Scientific. ISBN978-981270-532-7.
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Novikov, V.; Shifman, M.; Vainshtein, A.; Zakharov, V. (1983). "Exact Gell-Mann-Low function of supersymmetric Yang-Mills theories from instanton calculus". Nuclear Physics B. 229 (2): 381. Bibcode:1983NuPhB.229..381N. doi:10.1016/0550-3213(83)90338-3. Novikov, V.; Shifman, M.; Vainshtein, A.; Zakharov, V. (1986). "The beta function in supersymmetric gauge theories. Instantons versus traditional approach". Physics Letters B. 166 (3): 329. Bibcode:1986PhLB..166..329N. doi:10.1016/0370-2693(86)90810-5. Shifman, M.; Vainshtein, A. (1988). "On gluino condensation in supersymmetric gauge theories with SU(N) and O(N) groups". Nuclear Physics B. 296 (2): 445. Bibcode:1988NuPhB.296..445S. doi:10.1016/0550-3213(88)90680-3.