Michael Sela was born as Mieczysław Salomonowicz in Tomaszów Mazowiecki, Poland, on 2 March 1924.[3][4][5] In 1935 when he was 11 years old he and his family moved to Romania.[4][6] In 1941 when he was 17 years old he and his family immigrated to Mandatory Palestine.[4][7] He studied at the Hebrew University of Jerusalem (M.Sc., Chemistry, 1946; Ph.D., 1954).[8]
Sela was professor in the Weizmann Institute's Immunology Department. He was also a president of the Weizmann Institute of Science, from 1975 to 1985. He died in Rehovot on 27 May 2022 at the age of 98.[9]
Research
Sela is known for his research in immunology, particularly for research on synthetic antigens,[10]molecules that trigger the immune system to attack. This work of Sela has led to the discovery of the genetic control of the immune response, as well as to the design of vaccines based on synthetic molecules.
He was among the first who introduced the use of linear and branched synthetic polypeptides as antigens, and this brought about a better understanding of immunological phenomena.[11]
For several decades, Sela was interested in the possibility of fighting the autoimmune disease, experimental allergic encephalomyelitis[12] with synthetic analogs of the molecules in the myelin sheath of the brain which are capable of provoking the disease.
